Sequence of ROSB_STRDJ
EC Number:2.6.1.114
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
8-demethyl-8-aminoriboflavin-5'-phosphate synthase
K4REZ6
Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768)
257
28865
Reaction
8-demethyl-8-formylriboflavin 5'-phosphate + H2O + acceptor = 8-carboxy-8-demethylriboflavin 5'-phosphate + reduced acceptor
Other sequences found for EC No. 2.6.1.114
General information:
Sequence
0 MALKALILNT TLRRSPSRSQ TQGLIDKAVP LYEKEGIETE VVRVIDHDIE QEYWDDYDDW
60 NAGEKARRED EWPWLLEKIR EADILVIATP ITLNMCTSAA HVILEKLNLM DELNGDTKQF
120 PLYNKVAGLL MCGNEDGAHH VAGTVLNNLG RLGYSVPPNA AAYWLGPAGT GPGYIEGKGD
180 RHFHTNKLIR FMVANTSHLA RMLQETPYTT DLEACAQAAR EESDDVFAIR VNVNTPAIRY
240 KRFQKLGEVK VEESQLG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
728464
Jankowitsch F.,Schwarz J.,Ruckert C.,Gust B.,Szczepanowski R.,Blom J.,Pelzer S.,Kalinowski J.,Mack M.
Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and heterologous production of the unique antibiotic roseoflavin.
J. Bacteriol.
194
6818-6827
2012
728465
Schwarz J.,Konjik V.,Jankowitsch F.,Sandhoff R.,Mack M.
Identification of the Key enzyme of roseoflavin biosynthesis.
Angew. Chem. Int. Ed.
55
6103-6106
2016
728466
Jhulki I.,Chanani P.K.,Abdelwahed S.H.,Begley T.P.
A remarkable oxidative cascade that replaces the riboflavin C8 methyl with an amino group during roseoflavin biosynthesis.
J. Am. Chem. Soc.
138
8324-8327
2016
728467
Konjik V.,Brunle S.,Demmer U.,Vanselow A.,Sandhoff R.,Ermler U.,Mack M.
The crystal structure of RosB: insights into the reaction mechanism of the first member of a family of flavodoxin-like enzymes.
Angew. Chem. Int. Ed.
56
1146-1151
2017
