Sequence of F6BL85_THEXL
EC Number:3.2.1.21
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
beta-glucosidase
F6BL85
Thermoanaerobacterium xylanolyticum (strain ATCC 49914 / DSM 7097 / LX-11)
806
92472
Reaction
celloheptaose + 6 H2O = 7 beta-D-glucose
Other sequences found for EC No. 3.2.1.21
EC Number:3.2.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a D-glucosyl-N-acylsphingosine + H2O = D-glucose + a ceramide
Other sequences found for EC No. 3.2.1.45
General information:
Sequence
0 MRKVIILLFI FIFTISAILT GCSEKININE DKISHKIDIP DSAWTIGIGE KFKNAGHPNV
60 KYPMIDDSYV QGAPLGGFGA GTIGRTYNGG FSRWHLEIGK NKYTTVYANQ FSVFQKVEGN
120 KDGVAQVLYA GEPENGYLSS WKWDYPKESG MYYALYPNSW YTYTNKDLPV QLAVKQFSPI
180 IPYNYKETSY PVAVFKWTAY NPTNKNVDVS IMFTWQNMIG FFGKQVNVNS GNFNKIIKDK
240 SKDSEIVAAV MGNISNDNEE WNGEYSIGVK KVPGVDISYK AKFVTTGDGS DLWHEFSKNG
300 ILDNKDDETP TKQDGIGSAI AVNFKLQPGQ TIEVPFALSW DLPIMKFGGG DKWYKMYTKY
360 FGKNGKNSFA ILKEALNNYQ KWEKMIDDWQ KPILSNKSKP DWYKTALFNE LYYLADGGTA
420 WENGKVGEKD KRTNNMFGLL ECFDYNYYET LDVRFYGSFP LVMLWPDIEK QVMRQFADTI
480 NVQDSSEFKV GSNGAMAVKK VQGMIPHDLG SSYALPWIKI NAYDWQNPNI WKDLNSKYVL
540 LVYRDYVLTG KTDKEFLKYT WKSVKTALDK LKEMDKDNDG IPDNEGIPDQ TYDTWSMKGT
600 SAYCGSLWLA ALKAAQEIGK VLKDNEAYIK YNEWYKIAQQ NFEKELWNGE YYNFDTESDH
660 KDSIMADQLA GQWYADILRL GDILPKDHVQ KALKKIYEFN VMKFENGKMG AVNGMRPDGI
720 VDESDIQAQE VWTGVTYALA SFMKYRGMTE EAYNTAYGVY KMTYDKSGKG YWFRTPEAWT
780 KDGNYRASMY MRPLSIWSME VNYNEV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
47027346
Charoenwattanasatien R.,Pengthaisong S.,Breen I.,Mutoh R.,Sansenya S.,Hua Y.,Tankrathok A.,Wu L.,Songsiriritthigul C.,Tanaka H.,Williams S.J.,Davies G.J.,Kurisu G.,Cairns J.R.
Bacterial beta-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2).
ACS Chem. Biol.
11
1891-1900
2016
47027347
Artola M.,Wu L.,Ferraz M.J.,Kuo C.L.,Raich L.,Breen I.Z.,Offen W.A.,Codee J.D.C.,van der Marel G.A.,Rovira C.,Aerts J.M.F.G.,Davies G.J.,Overkleeft H.S.
1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.
ACS Cent. Sci.
3
784-793
2017
47027348
Lahav D.,Liu B.,van den Berg R.J.B.H.N.,van den Nieuwendijk A.M.C.H.,Wennekes T.,Ghisaidoobe A.T.,Breen I.,Ferraz M.J.,Kuo C.L.,Wu L.,Geurink P.P.,Ovaa H.,van der Marel G.A.,van der Stelt M.,Boot R.G.,Davies G.J.,Aerts J.M.F.G.,Overkleeft H.S.
A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.
J. Am. Chem. Soc.
139
14192-14197
2017
47027349
Schroder S.P.,Wu L.,Artola M.,Hansen T.,Offen W.A.,Ferraz M.J.,Li K.Y.,Aerts J.M.F.G.,van der Marel G.A.,Codee J.D.C.,Davies G.J.,Overkleeft H.S.
Gluco-1 H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor.
J. Am. Chem. Soc.
140
5045-5048
2018
47027350
Pengthaisong S.,Hua Y.,Ketudat Cairns J.R.
Structural basis for transglycosylation in glycoside hydrolase family GH116 glycosynthases.
Arch. Biochem. Biophys.
706
108924-108924
2021
