Sequence of A5K8L9_PLAVS
EC Number:2.1.2.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine
Other sequences found for EC No. 2.1.2.1
General information:
Sequence
0 MFNNEPLEQI DKELHDILAD EEKRQRETIN LIASENLTNG AVRECLGNRV SNKYSEGYPK
60 KRYYGGNDFI DKIEELCQKR ALEAFNVSDE EWGVNVQPLS GSAANVQALY ALVGVKGKIM
120 GMHLCSGGHL THGFFDEKKK VSITSDMFES KLYKCNSQGY VDLDAVREMA LSFKPKVIIC
180 GYTSYPRDID YQQFRQICDE VNAYLFADIS HISSFVACNI LNNPFLHADV VTTTTHKILR
240 GPRSALIFFN KKRNPGIEQK INSAVFPSFQ GGPHNNKIAA VACQLKEVHS PAFKEYTQQV
300 LLNSKALAKA LISKQIDLVT NGTDNHLIVV DLRKFSITGS KLQETCNAIN VSLNKNTIPS
360 DVDCVSPSGV RIGTPAMTTR GAKEKDMEFI ADVLARAIKI TVDLQEQYGK KLVDFKKGLP
420 GNAQLQQLKQ EVVTWAGALP FP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
212181434
Carlton J.M.,Adams J.H.,Silva J.C.,Bidwell S.L.,Lorenzi H.,Caler E.,Crabtree J.,Angiuoli S.V.,Merino E.F.,Amedeo P.,Cheng Q.,Coulson R.M.,Crabb B.S.,Del Portillo H.A.,Essien K.,Feldblyum T.V.,Fernandez-Becerra C.,Gilson P.R.,Gueye A.H.,Guo X.,Kang'a S.,Kooij T.W.,Korsinczky M.,Meyer E.V.,Nene V.,Paulsen I.,White O.,Ralph S.A.,Ren Q.,Sargeant T.J.,Salzberg S.L.,Stoeckert C.J.,Sullivan S.A.,Yamamoto M.M.,Hoffman S.L.,Wortman J.R.,Gardner M.J.,Galinski M.R.,Barnwell J.W.,Fraser-Liggett C.M.
Comparative genomics of the neglected human malaria parasite Plasmodium vivax.
Nature
455
757-763
2008
212181435
Chitnumsub P.,Jaruwat A.,Riangrungroj P.,Ittarat W.,Noytanom K.,Oonanant W.,Vanichthanankul J.,Chuankhayan P.,Maenpuen S.,Chen C.J.,Chaiyen P.,Yuthavong Y.,Leartsakulpanich U.
Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.
Acta Crystallogr. D
70
3177-3186
2014
212181436
Witschel M.C.,Rottmann M.,Schwab A.,Leartsakulpanich U.,Chitnumsub P.,Seet M.,Tonazzi S.,Schwertz G.,Stelzer F.,Mietzner T.,McNamara C.,Thater F.,Freymond C.,Jaruwat A.,Pinthong C.,Riangrungroj P.,Oufir M.,Hamburger M.,Maser P.,Sanz-Alonso L.M.,Charman S.,Wittlin S.,Yuthavong Y.,Chaiyen P.,Diederich F.
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.
J. Med. Chem.
58
3117-3130
2015
212181437
Schwertz G.,Frei M.S.,Witschel M.C.,Rottmann M.,Leartsakulpanich U.,Chitnumsub P.,Jaruwat A.,Ittarat W.,Schafer A.,Aponte R.A.,Trapp N.,Mark K.,Chaiyen P.,Diederich F.
Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs.
Chemistry
23
14345-14357
2017
212181438
Schwertz G.,Witschel M.C.,Rottmann M.,Bonnert R.,Leartsakulpanich U.,Chitnumsub P.,Jaruwat A.,Ittarat W.,Schafer A.,Aponte R.A.,Charman S.A.,White K.L.,Kundu A.,Sadhukhan S.,Lloyd M.,Freiberg G.M.,Srikumaran M.,Siggel M.,Zwyssig A.,Chaiyen P.,Diederich F.
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures.
J. Med. Chem.
60
4840-4860
2017
