EC Number   |
Protein Variants |
Reference |
|---|
    6.3.2.17 | A155H |
drastic increases in Km values |
690928 |
| 6.3.2.17 | A155W |
13fold increase in Km value for dihydropteroate |
690928 |
| 6.3.2.17 | A173S/Q536E |
cell line V79 compared to wild-type CHO-K1 cells, also with silent polymorphisms at codons 94 and 187 |
745311 |
| 6.3.2.17 | A22G |
a naturally occuring mutation, rs10760502 , phenotype, overview. The genotypes of the A22G polymorphism may be risk factors for acute lymphoblastic leukemia (ALL) and may play a role in the survival of patients with ALL |
745936 |
| 6.3.2.17 | A337V |
L44 cells |
652031 |
| 6.3.2.17 | A382T |
94% of the wild type enzyme activity |
675734 |
| 6.3.2.17 | A447V |
does not affect enzyme activity |
672921 |
| 6.3.2.17 | C209R |
8% of the wild type enzyme activity |
675734 |
| 6.3.2.17 | C346A |
activity comparable with that of wild type enzyme |
651947 |
| 6.3.2.17 | C346F |
MTXR5 antifolates-resistant cell subline |
651536 |
