EC Number   |
Protein Variants |
Reference |
|---|
   5.6.1.3 | A133D |
ispinesib-resistant KSP mutant |
687306 |
| 5.6.1.3 | A133D |
substantially reduced sensitivity to ispinesib and other quinazoline Eg5 inhibitors |
689127 |
| 5.6.1.3 | A247C |
mutation in loop L11. Mutant retains normal enzymatic properties |
687450 |
| 5.6.1.3 | A356T |
substantially reduced sensitivity to ispinesib and other quinazoline Eg5 inhibitors |
689127 |
| 5.6.1.3 | D130V |
ispinesib-resistant KSP mutant |
687306 |
| 5.6.1.3 | D130V |
mutation in the loop 5 region of the motor domain, screen of inhibitors against this mutant |
688256 |
| 5.6.1.3 | D130V |
substantially reduced sensitivity to ispinesib and other quinazoline Eg5 inhibitors |
689127 |
| 5.6.1.3 | I299F |
substantially reduced sensitivity to ispinesib and other quinazoline Eg5 inhibitors |
689127 |
| 5.6.1.3 | K196A |
motor domain, no activity |
-, 720501 |
| 5.6.1.3 | L249C |
mutation in loop L11. Vmax value is reduced by 20%. After modification by 4-phenylazophenyl maleimide, mutant exhibits reversible alterations in ATPase activity accompanied by cis-trans isomerization upon UV and VIS light irradiation. The APTase activity exhibited by the cis-isomer of the 4-phenylazophenyl maleimide bound to the mutant is half of that of the trans-isomer |
687450 |
