EC Number   |
Protein Variants |
Reference |
|---|
   3.4.21.53 | D241A |
99% of wild-type peptidase activity |
668596 |
| 3.4.21.53 | D508A |
reduction of enzymic activity |
669861 |
| 3.4.21.53 | D676N |
is completely inactive for protein degradation, it retains some basal ATPase activity, but no activation of ATPase activity occurs upon binding of protein substrates |
682726 |
| 3.4.21.53 | D676N |
site-directed mutagenesis |
651238 |
| 3.4.21.53 | D743N |
site-directed mutagenesis |
651238 |
| 3.4.21.53 | D93A |
mutations result in efficient splicing |
717190 |
| 3.4.21.53 | delta75-490 |
dominant negative mutant, exhibits a remarkable decrease in acyl-CoA oxidase and mislocalization of catalase to the cytoplasm. Shows lower beta-oxidation activity than wild-type |
680569 |
| 3.4.21.53 | deltaTM(1)-lon-S509A |
possesses neither proteolytic nor ATPase activity, is completely stable, can be considered as model of initial active delta TM(1)-lon forms |
682848 |
| 3.4.21.53 | deltaTM(2)-lon-S509A |
possesses neither proteolytic nor ATPase activity, is completely stable, can be considered as model of initial active delta TM(2)-lon forms |
682848 |
| 3.4.21.53 | deltaTM1-lon |
deletion of 100-186, leads to the removal of the predicted hydrophobic site of the transmembrane domain |
682848 |
