EC Number   |
Protein Variants |
Reference |
|---|
    3.1.1.23 | A76G |
reduced thermostability, increased stability at pH 5-7, substitution converts the esterase into a monoacylglycerol hydrolase |
651084 |
| 3.1.1.23 | C201A |
substantial decrease in the inhibitory potential |
708116 |
| 3.1.1.23 | C201A |
the mutation causes a significant reduction in overall activity particularly skewing the balanced hydrolysis of monoacyl glycerol isomers to favor the 2-isomer over the 1-isomer |
730423 |
| 3.1.1.23 | C201A/C208A/C242A |
no significant inhibition by N-arachidonylmaleimide |
708116 |
| 3.1.1.23 | C201G |
causes significant decreases in enzyme activity, albeit smaller than that produced by mutant C242G. Inhibitory potency of N-arachidonylmaleimide is selectively decreased |
707916 |
| 3.1.1.23 | C208A |
increase in the inhibiting power of N-arachidonylmaleimide |
708116 |
| 3.1.1.23 | C208A |
the mutation causes a significant reduction in overall activity particularly skewing the balanced hydrolysis of monoacyl glycerol isomers to favor the 2-isomer over the 1-isomer |
730423 |
| 3.1.1.23 | C208A |
the mutation does not affect enzyme catalytic activity |
716186 |
| 3.1.1.23 | C208A/C242A |
increase in the inhibiting power of N-arachidonylmaleimide |
708116 |
| 3.1.1.23 | C208G |
causes significant decreases in enzyme activity, albeit smaller than that produced by mutant C242G. Inhibitory potency of octhilinone is selectively decreased. Has no effect on the inhibitory potency of N-arachidonylmaleimide |
707916 |
