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Protein Variants:
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EC Number
Protein Variants
Commentary
Reference
2.7.11.20
C314A
complete loss of activity
721536
2.7.11.20
C318A
complete loss of activity
721536
2.7.11.20
D274A
loss of ability to bind ATP
721536
2.7.11.20
D284A
catalytically inactive
761472
2.7.11.20
D97A
site-directed mutagenesis
740996
2.7.11.20
E717A
the mutation in the C-terminal fragment of the enzyme reduces elongation factor 2 phosphorylation activity
760579
2.7.11.20
H213A
complete loss of activity
721536
2.7.11.20
H260A
complete loss of activity
721536
2.7.11.20
K170M
complete loss of activity, loss of ability to bind ATP
721536
2.7.11.20
K170R
complete loss of activity, loss of ability to bind ATP
721536
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