EC Number |
Protein Variants |
Reference |
---|
2.5.1.21 | A177N |
site-directed mutagenesis, mutant substrate specificity and activity compared to the wild-type |
741903 |
2.5.1.21 | A177N/Q213G |
site-directed mutagenesis, mutant substrate specificity and activity compared to the wild-type, the mutant has lost the first reaction step but retains a greater level of the second reaction step for the conversion of presqualene diphosphate to squalene |
741903 |
2.5.1.21 | D220A |
site-directed mutagenesis, mutant substrate specificity and activity compared to the wild-type |
741903 |
2.5.1.21 | D224A |
site-directed mutagenesis, mutant substrate specificity and activity compared to the wild-type |
741903 |
2.5.1.21 | D280E |
enzymic activity slightly above wild-type activity |
658181 |
2.5.1.21 | D280P |
enzymic activity about 74% of wild-type activity |
658181 |
2.5.1.21 | D280Q |
enzymic activity about 50% of wild-type activity |
658181 |
2.5.1.21 | D58E |
site-directed mutagenesis of the DXXED motif (S1 site), almost inactive mutant |
738214 |
2.5.1.21 | D58L |
site-directed mutagenesis of the DXXED motif (S1 site), almost inactive mutant |
738214 |
2.5.1.21 | D58N |
site-directed mutagenesis of the DXXED motif (S1 site), almost inactive mutant |
738214 |