EC Number   |
Protein Variants |
Reference |
|---|
   2.1.1.360 | F326A |
the mutant shows significantly decreased enzyme activity compared to the wild type |
753746 |
| 2.1.1.360 | F326A |
the mutation abrogates the stimulation of enzyme activity L by histone H2B lysine 120 ubiquitin |
754713 |
| 2.1.1.360 | I290A |
the mutant shows significantly decreased enzyme activity compared to the wild type |
753746 |
| 2.1.1.360 | I290D |
the mutation abrogates the stimulation of enzyme activity L by histone H2B lysine 120 ubiquitin |
754713 |
| 2.1.1.360 | L284A |
the mutant shows significantly decreased enzyme activity compared to the wild type |
753746 |
| 2.1.1.360 | L322D |
the mutation abrogates the stimulation of enzyme activity L by histone H2B lysine 120 ubiquitin |
754713 |
| 2.1.1.360 | more |
methyltransferase-dead mutant pEGFP-mDot1aRCR, mENaCalpha mRNA levels in cells transfected with the methyltransferase-dead mutant are almost twice that of vector-transfected cells, knockdown of mDot1a mRNA levels by RNA interference augments endogenous mENaCalpha expression and activity of mENaCalpha-promoter luciferase reporter |
671225 |
| 2.1.1.360 | more |
mutations in enzyme gene result in Polycomb-group phenotypes, phenotypes characteristic of trithorax-group mutants, disrupt telomeric silencing, but do not affect centric heterochromatin |
661834 |
| 2.1.1.360 | R278E/R282E |
the mutant shows a significant decrease in both di- and trimethylation of histone H3 lysine 79 compared to the wild type enzyme |
754713 |
| 2.1.1.360 | R282A |
the mutant shows dramatically decreased enzyme activity compared to the wild type |
753746 |
