EC Number   |
|---|
    2.7.4.9 | - |
| 2.7.4.9 | cocrystallization with TMP and potential inhibitors |
| 2.7.4.9 | cocrystals with 3-azido-3-deoxythymidine 5'-monophosphate and deoxythymidine |
| 2.7.4.9 | crystallographic structures of the mutant F105Y enzyme in complex with either TMP or 3'-azido-3'-deoxythymidine monophosphate show that the mutation shifts the P-loop to a position that is similar to that found in the complex between Ap5dT and the wild-type enzyme |
| 2.7.4.9 | For the His-tagged SaTMK crystals, data is collected on beamline ID 14.1 at the ESRF (Grenoble, France). |
| 2.7.4.9 | hanging drop method, three-dimensional structure of the enzyme in its apo and ADP-bound forms |
| 2.7.4.9 | hanging drop vapor diffusion method |
| 2.7.4.9 | hanging drop vapor diffusion method, using 30% (w/v) PEG 4000, 0.2 M MgCl2, and 0.1 M Tris, pH 7.5-8.5, at 22°C |
| 2.7.4.9 | high-resolution X-ray crystal structures of thymidylate kinase in apo and ligand-bound states, structures of binary and ternary complexes of thymidylate kinase with its natural substrates ATP and ATP-TMP, respectively |
| 2.7.4.9 | in comlplex with inhibitors 4-[3-cyano-6-(3-methoxyphenyl)-2-oxo-1H-pyridin-4-yl]benzoic acid, 4-[3-cyano-2-oxo-7-(1H-pyrazol-4-yl)-5,6-dihydro-1H-benzo[h]quinolin-4-yl]benzoic acid |
