EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.5.1.125 | dimethylallyl diphosphate + flaviolin |
- |
Streptomyces sp. |
? |
- |
? |
2.5.1.125 | geranyl diphosphate + 1,3-dihydroxynaphthalene |
- |
Streptomyces sp. |
? |
- |
? |
2.5.1.125 | geranyl diphosphate + 2-O-methyl-3-methylflaviolin |
the enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin. It catalyses the transfer of a geranyl group to 2-O-methyl-3-methyl-flaviolin to yield 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione and 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione in a 1:10 ratio |
Streptomyces sp. |
diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione |
- |
? |
2.5.1.125 | geranyl diphosphate + 2-O-methyl-3-methylflaviolin |
the enzyme catalyses the transfer of a geranyl group to 2-O-methyl-3-methyl-flaviolin to yield 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione and 6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione in a 1:10 ratio |
Streptomyces sp. |
diphosphate + 7-[[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy]-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione |
- |
? |
2.5.1.125 | geranyl diphosphate + flaviolin |
i.e. 2,5,7-trihydroxynaphthalene-1,4-dione. The kcat/Km of the prenylation of flaviolin is significantly higher than that of the prenylation of the natural substrate 2-O-methyl-3-methylflaviolin |
Streptomyces sp. |
diphosphate + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,5,7-trihydroxynaphthalene-1,4-dione |
- |
? |
2.5.1.125 | geranyl diphosphate + flaviolin |
- |
Streptomyces sp. |
diphosphate + 3-(3,7-dimethylocta-1,6-dien-3-yl)-2,5,7-trihydroxynaphthalene-1,4-dione |
- |
? |