EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.21 | aldose reductase |
Caco-2 cell |
- |
685925, 722714 |
1.1.1.21 | aldose reductase |
Caco-2 cell |
colon cancer cell line |
668165 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
Caco-2 cell |
- |
711694 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
Caco-2 cell |
colon epithelial cell line, isozyme HSD2 |
667152 |
1.11.1.6 | catalase |
Caco-2 cell |
adrenocortical tumor cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms |
655696 |
1.11.1.6 | catalase |
Caco-2 cell |
colon tumor cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms |
655696 |
1.13.11.33 | arachidonate 15-lipoxygenase |
Caco-2 cell |
- |
706877 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
Caco-2 cell |
intestinal cell line Caco-2/subclone TC7 |
438232, 438238 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
Caco-2 cell |
when TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence |
438232 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
Caco-2 cell |
- |
676834 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
Caco-2 cell |
- |
745525 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
Caco-2 cell |
- |
745525 |
1.14.12.17 | nitric oxide dioxygenase |
Caco-2 cell |
- |
658796 |
1.14.15.18 | calcidiol 1-monooxygenase |
Caco-2 cell |
- |
440130, 672936, 712885 |
1.14.15.18 | calcidiol 1-monooxygenase |
Caco-2 cell |
intestinal cell line, both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation |
677255 |
1.15.1.1 | superoxide dismutase |
Caco-2 cell |
- |
745523 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
Caco-2 cell |
a colon adenocarcinoma cell line |
688283 |
1.3.1.72 | DELTA24-sterol reductase |
Caco-2 cell |
intestinal mucosa cells |
654502 |
1.4.3.22 | diamine oxidase |
Caco-2 cell |
- |
765044 |
1.5.3.17 | non-specific polyamine oxidase |
Caco-2 cell |
- |
764224 |
1.6.2.4 | NADPH-hemoprotein reductase |
Caco-2 cell |
- |
658948 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
Caco-2 cell |
- |
685016, 711166 |
1.6.5.10 | NADPH dehydrogenase (quinone) |
Caco-2 cell |
- |
696015 |
1.8.1.9 | thioredoxin-disulfide reductase |
Caco-2 cell |
- |
687225 |
1.8.3.4 | methanethiol oxidase |
Caco-2 cell |
methanethiol oxidase activity is strongly enhanced in Caco-2 cells upon enterocyte differentiation, in parallel with increased SELENBP1 levels |
765747 |
2.1.1.13 | methionine synthase |
Caco-2 cell |
adenocyrcinoma cell line |
658413 |
2.1.1.319 | type I protein arginine methyltransferase |
Caco-2 cell |
- |
756861 |
2.1.1.366 | [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase |
Caco-2 cell |
- |
759760 |
2.3.1.20 | diacylglycerol O-acyltransferase |
Caco-2 cell |
- |
672340 |
2.3.1.22 | 2-acylglycerol O-acyltransferase |
Caco-2 cell |
- |
672340 |
2.3.1.291 | sphingoid base N-palmitoyltransferase |
Caco-2 cell |
- |
753514 |
2.3.1.57 | diamine N-acetyltransferase |
Caco-2 cell |
colon cancer cells Caco-2 and HTC-116 |
487270 |
2.3.1.57 | diamine N-acetyltransferase |
Caco-2 cell |
induction by aspirin and different non-steroidal anti-inflammatory drugs |
671847 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
Caco-2 cell |
- |
702406 |
2.3.1.76 | retinol O-fatty-acyltransferase |
Caco-2 cell |
- |
658662 |
2.3.1.76 | retinol O-fatty-acyltransferase |
Caco-2 cell |
colon cancer cell line |
672340 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
Caco-2 cell |
Caco-2 intestinal cancer cells express crosslinking-competent tTG on their surface |
759712 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
Caco-2 cell |
cell line derived from human colon carcinoma |
487859 |
2.3.3.10 | hydroxymethylglutaryl-CoA synthase |
Caco-2 cell |
enzyme is a direct target of c-Myc, which represses hydroxymethylglutaryl-CoA synthase transcriptional activity |
675910 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
638293 |
2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
658123 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
658123 |
2.4.1.145 | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
high activity |
658123 |
2.4.1.146 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
638293 |
2.4.1.147 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase |
Caco-2 cell |
expression of the enzyme is markedly down-regulated in gastric and colorectal carcinomas |
660389 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
658123 |
2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase |
Caco-2 cell |
- |
488679, 686976 |
2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase |
Caco-2 cell |
colon carcinoma cell |
659083 |
2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase |
Caco-2 cell |
enzymic activity correlates with the degree of enterocytic differentiation |
488682 |
2.4.1.17 | glucuronosyltransferase |
Caco-2 cell |
- |
675803, 735649 |
2.4.1.17 | glucuronosyltransferase |
Caco-2 cell |
low-level UGT1A5 expression |
675594 |
2.4.1.65 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase |
Caco-2 cell |
- |
736582 |
2.4.1.90 | N-acetyllactosamine synthase |
Caco-2 cell |
colon adenocarcinoma cell line |
658123 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
Caco-2 cell |
- |
760043 |
2.4.3.2 | beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase |
Caco-2 cell |
type 2 mRNA isoform, type 1 mRNA isoform is not detected |
744211 |
2.5.1.57 | N-acylneuraminate-9-phosphate synthase |
Caco-2 cell |
- |
671800 |
2.6.1.13 | ornithine aminotransferase |
Caco-2 cell |
- |
688566 |
2.7.1.105 | 6-phosphofructo-2-kinase |
Caco-2 cell |
- |
749587 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
Caco-2 cell |
- |
762015 |
2.7.1.48 | uridine/cytidine kinase |
Caco-2 cell |
- |
673504 |
2.7.10.1 | receptor protein-tyrosine kinase |
Caco-2 cell |
- |
674071 |
2.7.11.10 | IkappaB kinase |
Caco-2 cell |
- |
693131 |
2.7.11.13 | protein kinase C |
Caco-2 cell |
- |
676258 |
2.7.11.18 | myosin-light-chain kinase |
Caco-2 cell |
- |
689353, 709236, 709287, 760849, 761603 |
2.7.11.18 | myosin-light-chain kinase |
Caco-2 cell |
endothelial cell, 2 isozymes MLCK1 and MLCK2 |
662316 |
2.7.6.2 | thiamine diphosphokinase |
Caco-2 cell |
- |
762080 |
2.7.7.1 | nicotinamide-nucleotide adenylyltransferase |
Caco-2 cell |
- |
737971 |
2.7.8.27 | sphingomyelin synthase |
Caco-2 cell |
isozymes SMS1 and SMS2 |
692991 |
2.8.2.1 | aryl sulfotransferase |
Caco-2 cell |
- |
705075, 738482, 760663, 760970 |
2.8.2.14 | bile-salt sulfotransferase |
Caco-2 cell |
- |
676007 |
2.8.2.15 | steroid sulfotransferase |
Caco-2 cell |
- |
676007, 738552 |
2.8.2.2 | alcohol sulfotransferase |
Caco-2 cell |
- |
738482 |
2.8.2.5 | chondroitin 4-sulfotransferase |
Caco-2 cell |
- |
760531 |
3.1.1.1 | carboxylesterase |
Caco-2 cell |
- |
729359, 749814 |
3.1.1.1 | carboxylesterase |
Caco-2 cell |
isozyme CE2 |
692036 |
3.1.1.116 | sn-1-specific diacylglycerol lipase |
Caco-2 cell |
- |
761578 |
3.1.1.23 | acylglycerol lipase |
Caco-2 cell |
- |
680845 |
3.1.1.43 | alpha-amino-acid esterase |
Caco-2 cell |
- |
715846, 729021 |
3.1.1.7 | acetylcholinesterase |
Caco-2 cell |
well-differentiated colonic adenocarcinoma cell line |
651202 |
3.1.2.22 | palmitoyl[protein] hydrolase |
Caco-2 cell |
exclusively localized to the basolateral side of the polarized cells |
651451 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
Caco-2 cell |
- |
749587 |
3.1.3.86 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
Caco-2 cell |
- |
751770 |
3.1.3.9 | glucose-6-phosphatase |
Caco-2 cell |
- |
751406 |
3.1.4.12 | sphingomyelin phosphodiesterase |
Caco-2 cell |
- |
664500, 682477, 705457, 705473 |
3.1.4.12 | sphingomyelin phosphodiesterase |
Caco-2 cell |
no mutation identified |
664532 |
3.1.6.4 | N-acetylgalactosamine-6-sulfatase |
Caco-2 cell |
- |
721758 |
3.2.1.10 | oligo-1,6-glucosidase |
Caco-2 cell |
- |
666140, 677949, 702506 |
3.2.1.108 | lactase |
Caco-2 cell |
- |
679123 |
3.2.1.108 | lactase |
Caco-2 cell |
fully differentiated, intestinal enterocyte-like cells |
679123 |
3.2.1.117 | amygdalin beta-glucosidase |
Caco-2 cell |
TC7 clone |
708783 |
3.2.1.118 | prunasin beta-glucosidase |
Caco-2 cell |
TC7 clone |
708783 |
3.2.1.48 | sucrose alpha-glucosidase |
Caco-2 cell |
- |
663852, 664558, 666140, 677949, 702506, 715559 |
3.2.1.51 | alpha-L-fucosidase |
Caco-2 cell |
- |
655418 |
3.2.1.62 | glycosylceramidase |
Caco-2 cell |
- |
679123 |
3.4.11.16 | Xaa-Trp aminopeptidase |
Caco-2 cell |
- |
643873 |
3.4.11.16 | Xaa-Trp aminopeptidase |
Caco-2 cell |
expressed both in undifferentiated and differentiated cell lines |
643874 |
3.4.11.6 | aminopeptidase B |
Caco-2 cell |
colorectal adenocarcinoma cell line |
666799 |
3.4.13.9 | Xaa-Pro dipeptidase |
Caco-2 cell |
- |
683964 |
3.4.14.5 | dipeptidyl-peptidase IV |
Caco-2 cell |
- |
681294, 681319, 696912, 697519, 699748, 701430 |
3.4.14.6 | dipeptidyl-dipeptidase |
Caco-2 cell |
enzyme activity is promoted by integrin subunit alpha2 blockade but decreased after subunit alpha6 blockade. Proliferative blockade using mitomycin C or hydroxyurea prevent the effects of subunit alpha2 ligation on differentiation |
668200 |