EC Number   |
General Information |
Reference |
|---|
    3.5.4.4 | malfunction |
apoptosis is enhanced in ADAR1-deficient cells following infection with wild type and V knockout measles virus but not following infection with C knockout measles virus or treatment with tumor necrosis factor-alpha or staurosporine |
712390 |
| 3.5.4.4 | malfunction |
disruption of TADA has profound effects on chloroplast translation efficiency, leading to reduced yields of chloroplast-encoded proteins and impaired photosynthetic function |
713269 |
| 3.5.4.4 | metabolism |
ADA is a key enzyme in the pathway of hypoxanthine formation |
711215 |
| 3.5.4.4 | metabolism |
comparison of growth characteristics including intracellular protein levels, RNA content, and nucleotide pool sizes between the extreme halophile Halobacterium halobium and the moderate halophile Haloferax volcanii. The differences in the metabolism of purine bases and nucleosides and the sensitivity to purine analogs between the two halobacteria are reflected in differences in purine enzyme levels |
734059 |
| 3.5.4.4 | metabolism |
important enzyme in the purine metabolism. Oxidative stress occurs in cattle experimentally infected by Fasciola hepatica, mainly due to excessive production of reactive oxygen species in the course of fasciolosis, contributing to hepatic damage. Increase in hepatic adenosine deaminase activity may contribute to the inflammatory process |
757907 |
| 3.5.4.4 | metabolism |
key enzyme involved in the purine metabolism |
756517 |
| 3.5.4.4 | metabolism |
Plasmodium falciparum, a malarial pathogen, can only synthesize purine nucleotides employing a salvage pathway because it lacks de novo biosynthesis. Adenosine deaminase, one of the three purine salvage enzymes |
755901 |
| 3.5.4.4 | metabolism |
the enzyme is involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens |
-, 727779 |
| 3.5.4.4 | physiological function |
ADAR1 deaminase increases exogenous gene expression at the translational level by decreasing protein kinase regulated by RNA-dependent eIF-2alpha phosphorylation |
712748 |
| 3.5.4.4 | physiological function |
ADAR1 is a proviral, antiapoptotic host factor in the context of measles virus infection. ADAR1 enhances the growth of measles virus. ADAR1 suppresses wild type and V knockout measles virus-induced apoptosis. ADAR1 does not protect against tumor necrosis factor-alpha- or staurosporine-induced apoptosis. ADAR1 suppresses wild type and V knockout measles virus-induced protein kinase regulated by RNA activation. ADAR1 suppresses interferon regulatory transcription factor-3 activation by wild type and V knockout measles viruses |
712390 |
