EC Number   |
General Information |
Reference |
|---|
   3.4.24.B4 | malfunction |
knockdown of MMP13 strongly enhances pigmentation of melanocytes |
720440 |
| 3.4.24.B4 | metabolism |
interleukin-1beta treatment induces COX-2 and MMP-13 expressions in association with activation of ERKs, p38 MAPK, JNKs, and NF-kappaB in skin fibroblasts. Phorbol-12-myristate-13-acetate treatment also induces COX-2 and MMP-13 expressions in association with p38 MAPK activation. Glucosamine-hydrochloride differentially downregulates COX-2 andMMP-13 expression in the interleukin-1beta- or phorpbol-12-myristate-13-acetate-treated skin fibroblasts via the p38 MAPK-independent COX-2 translational inhibition and the p38 MAPK-dependent MMP-13 transcriptional suppression, respectively |
712592 |
| 3.4.24.B4 | metabolism |
the activation of MMP-13 expression by T3 is in a competitive balance with the regulation of osteocalcin expression, overview |
711853 |
| 3.4.24.B4 | metabolism |
the prodomain of MMP13 determines autoactivation of MMP13 and intracellular degradation of MMP13 |
710801 |
| 3.4.24.B4 | more |
age-related accumulation of advanced glycation end products can activate chondrocytes and induce the production of proinflammatory cytokines and matrix metalloproteinases |
711043 |
| 3.4.24.B4 | more |
ALK1 and Alk5 are involved in MMP-13 activity regulation, age-related shift in ALK1/ALK5 ratio in murine cartilage. A change in balance between ALK5 and ALK1 receptors in chondrocytes causes changes in MMP-13 expression, thereby causing an osteoarthritis-like phenotype |
712636 |
| 3.4.24.B4 | more |
angiotensin II promotes a stable fibrotic phenotype by inducing severe intra-plaque hemorrhages, characterized by increased degradation of interstitial collagen I via an MMP13 or MMP8-mediated mechanism, overview |
711052 |
| 3.4.24.B4 | more |
cartilage ALK1 is highly correlated with MMP-13 expression, whereas ALK5 correlates with aggrecan and collagen type II expression. Strong correlation between ALK1 and MMP-13 expression in human cartilage |
712636 |
| 3.4.24.B4 | more |
cartilage structural damage in osteoarthritis in mice is dependent on MMP13 activity |
712933 |
| 3.4.24.B4 | more |
chloramphenicol-induced MMP-13 expression is strongly associated with metastatic capacity of solid-tumor cells |
713548 |
