EC Number   |
General Information |
Reference |
|---|
   3.4.22.36 | malfunction |
apoptosis is triggered upon bacterial infection in primary murine bone marrow macrophages lacking caspase-1 |
732557 |
| 3.4.22.36 | malfunction |
caspase 1 deficiency does not affect neutrophil-dominated joint inflammation, whereas in chronic arthritis, the lack of caspase 1 results in reduced joint inflammation and cartilage destruction |
707322 |
| 3.4.22.36 | malfunction |
decreased enzymatic activity of caspase-1 is compatible with normal life and does not prevent moderate and severe autoinflammation |
731897 |
| 3.4.22.36 | malfunction |
gene silencing of caspase-1 or inhibition of caspase-1 activity leads to reduction in dengue virus-induced apoptosis with minimal effect on virus replication |
709488 |
| 3.4.22.36 | malfunction |
infection with Mycobacterium leprae induces high levels of TNF-alpha production and NF-kappaB activation in macrophages of A/J mice (mutant mouse bearing amino acid differences in Naip5, one of the NOD-like receptors (NLRs), one of the adaptor proteins for caspase-1 activation) and C57BL/6 macrophages. Caspase-1 activation and IL-1beta secretion are also induced in both macrophages. Macrophages from A/J mice exhibit reduced caspase-1 activation and IL-1beta secretion compared to C57BL/6 macrophages |
718077 |
| 3.4.22.36 | malfunction |
release of truncated SphK2 into the supernatant is attenuated in caspase-1 knockdown cells |
717418 |
| 3.4.22.36 | metabolism |
caspase-1 is required for nuclear translocation of intracellular interleukin-37 and for secretion of mature interleukin-37 |
732829 |
| 3.4.22.36 | physiological function |
caspase 1 is a major regulator of the inflammation response |
708128 |
| 3.4.22.36 | physiological function |
caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop during Francisella infection |
731863 |
| 3.4.22.36 | physiological function |
caspase-1 activity is required for UVB-induced apoptosis of human keratinocytes and therefore plays a protective role of the protease in UVB-induced skin cancer development |
732293 |
