EC Number   |
General Information |
Reference |
|---|
   2.7.11.31 | evolution |
Saccharomyces cerevisiae expresses three isoforms of Snf1 kinase that differ by which beta subunit is present, Gal83, Sip1 or Sip2, abundance, activation, localization and signaling specificity of the three Snf1 isoforms, by quantitative immunoblotting and fluorescence microscopy, overview. The Gal83 containing isoform is the most abundant in all assays while the abundance of the Sip1 and Sip2 isoforms is typically underestimated especially in glass-bead extractions |
-, 740280 |
| 2.7.11.31 | evolution |
the AMPK beta-subunit CBM has a beta-sandwich fold with the conserved residues Trp100, Lys126 and Trp133 (residue numbers according to beta1-CBM), classifying it under the CBM48 family |
740016 |
| 2.7.11.31 | evolution |
the genes encoding the three subunits of AMPK are highly conserved in eukaryotic species for which complete genome sequences are available, including vertebrates, invertebrates, plants, fungi, and protozoa |
740129 |
| 2.7.11.31 | malfunction |
Agouti-related peptide alpha2 AMPK-KO mice show decreased body weight even though there are no changes in food intake or energy expenditure and, the difference in body weight is lost when the animals are fed a high fat diet. Pro-opiomelanocortin alpha2 AMPK-KO animals show increased body weight and adiposity, which is further enhanced by a high fat diet |
705267 |
| 2.7.11.31 | malfunction |
AMPK gamma2 mutations are associated with hypertrophic cardiomyopathy |
703348 |
| 2.7.11.31 | malfunction |
deletion of the SAK1 gene blocks nuclear translocation of Gal83 and signaling to Mig2 |
-, 740280 |
| 2.7.11.31 | malfunction |
enzyme ablation increases Zika virus replication and reduces innate antiviral responses |
761640 |
| 2.7.11.31 | malfunction |
germline deletion of either AMPK beta1 or beta2 subunit isoforms results in reduced trabecular bone density and mass, but without effects on osteoclast or osteoblast numbers, as compared to wild-type littermate controls |
-, 703618 |
| 2.7.11.31 | malfunction |
in the liver from beta1 knockout mice the gamma1 subunit is present but alpha1 and alpha2 are degraded |
701572 |
| 2.7.11.31 | malfunction |
knockout of AMPKalpha1 enhances, and, conversely, activator A-769662 inhibits monosodium urate crystal-induced inflammatory responses including IL-1beta and CXCL1 release in vitro and in vivo |
-, 739863 |
