EC Number   |
General Information |
Reference |
|---|
    2.4.2.4 | evolution |
the amino acid sequence of thymidine phosphorylase (TP) is extremely conserved. For instance, human TP shares 39% sequence identity with Escherichia coli TP |
759143 |
| 2.4.2.4 | evolution |
the enzyme is identical to the platelet-derived endothelial cell growth factor (PD-ECGF). Amino acid sequence homology between hepatic thymidine phosphorylase and PD-ECGF |
760039 |
| 2.4.2.4 | malfunction |
a loss-of-function mutation is involved in mitochondrial neurogastrointestinal encephalomyopathy, an autosomal recessive human disorder associated with multiple deletions of skeletal muscle mitochondrial DNA, overview. Corrleation of tumor development and progression with intratumoral thymidine phsophorylase levels, overview |
705495 |
| 2.4.2.4 | malfunction |
collagen-, collagen-related peptide-, adenosine diphosphate-and/or thrombin-induced platelet aggregation are significantly attenuated in enzyme deficient platelets. Tymp deficiency also significantly decreases agonist-induced P-select in expression |
735971 |
| 2.4.2.4 | malfunction |
deficiency of the cytosolic enzyme thymidine phosphorylase causes a multisystem disorder called mitochondrial neurogastrointestinal encephalomyopathy syndrome with symptoms gastrointestinal dysfunction, muscle involvement and neurological deterioration, overview |
704973 |
| 2.4.2.4 | malfunction |
EGF receptor inhibition may lead to TP overexpression, which decreases the efficacy of infusional 5-fluorouracil (5FU) regimens, while enhancing that of bolus schedules. Tissue hypoxia secondary to low hemoglobin levels may induce TP overexpression, and subsequently, a relative resistance to infusional 5FU |
759291 |
| 2.4.2.4 | malfunction |
knocking down enzyme expression enhances the cytotoxicity and cell growth inhibition of tamoxifen |
735645 |
| 2.4.2.4 | malfunction |
mutation of the TP gene is associated with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease exhibiting multiple deletions of skeletal muscle mitochondrial DNA (peripheral neuropathy, myopathy, leukoencephalopathy, lactic acidosis, gastrointestinal dysmotility, progressive external ophthalmoplegia, and thin body habitus) |
760039 |
| 2.4.2.4 | malfunction |
overexpression of human thymidine phosphorylase (hTP) has been associated with cancer aggressiveness and poor prognosis by triggering proangiogenic and antiapoptotic signaling |
759610 |
| 2.4.2.4 | malfunction |
overexpression of thymidine phosphorylase (TP) causes diseases like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. The inhibition of this enzyme is vital to secure life from serious threats |
760181 |
