EC Number   |
General Information |
Reference |
|---|
    2.3.1.180 | evolution |
enzymes FabH from Gram-positive and Gram-negative bacteria are known to have distinct preferences for acyl-CoA primers. This is functionally important, as the substrate specificity of the enzyme governs the fatty acid profile of the organism. FabH from Escherichia coli and other Gram-negative organisms are selective for acetyl-CoA and produce straight-chain fatty acids, while the FabH enzymes of Gram-positive bacteria such as bacilli prefer branched-chain primers and produce branched-chain fatty acids |
-, 736658 |
| 2.3.1.180 | evolution |
FabH is prevalent and necessary in a large number of clinical pathogens, such as Gram-positive and -negative bacteria, anaerobic bacteria, mycobacteria, chlamydia, and protozoa |
-, 735963 |
| 2.3.1.180 | metabolism |
beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria |
-, 703762 |
| 2.3.1.180 | metabolism |
catalytic model, a structurally disordered apo-ecFabH dimer orders on binding either the first substrate, acetyl-CoA, or the inhibitor MeSSCoA, and is restored to a disordered state on binding of malonyl-ACP |
760858 |
| 2.3.1.180 | metabolism |
enzyme FabH catalyzes the initiation reaction of fatty acid biosynthesis |
736053 |
| 2.3.1.180 | metabolism |
enzyme overexpression increases pinocembrin production in recombinant Escherichia coli |
757353 |
| 2.3.1.180 | metabolism |
FabB, FabF, and FabH are the condensing enzymes in te fatty acid synthesis system FAS II that play an important role in the initiation and elongation of fatty acid chains. FabB and FabF use acyl-ACPs as primers, while FabH uses acetyl-CoA as an acyl donor, which makes it unique among the FAS II condensing enymes |
736551 |
| 2.3.1.180 | metabolism |
FabH catalyzes the first condensation of acetyl-CoA with malonyl-ACP to form beta-ketobutyryl-ACP and CO2, initiating the cycle of fatty acid elongation, FASII pathway, detailed overview |
-, 735963 |
| 2.3.1.180 | metabolism |
isoforms FabH1 and FabH2 have major roles in straight-chain fatty acid and branched-chain fatty acid biosynthesis, respectively |
-, 756089 |
| 2.3.1.180 | metabolism |
KASIII is involved in the biosynthesis of short-chain-length/medium-chain-length polyhydroxyalkanoate, pathway overview |
702531 |
