EC Number   |
General Information |
Reference |
|---|
   2.1.1.360 | malfunction |
enzyme deletion impedes leukemia cell proliferation as well as switches exon skipping to the inclusion isoform in MLL-rearranged acute myeloid leukemia cell lines |
753750 |
| 2.1.1.360 | malfunction |
enzyme inhibition leads to increased sensitivity to chemotherapeutic agents and PARP inhibition |
753305 |
| 2.1.1.360 | malfunction |
enzyme knockdown enhances cell fusion and resorption activity in RAW264.7 osteoclastogenesis model. Enzyme inhibition enhances bone loss in ovariectomized mice |
753191 |
| 2.1.1.360 | malfunction |
enzyme knockdown reduces histone H3 lysine 79 methylation and N-Myc protein binding at the ODC1 and E2F2 gene promoters and reduces neuroblastoma cell proliferation |
753144 |
| 2.1.1.360 | malfunction |
enzyme knockdown severely retards the growth of the tadpoles and leads to tadpole lethality prior to metamorphosis |
753528 |
| 2.1.1.360 | malfunction |
failure to recruit Rad9 or Dot1 to histone H3 leads to an increase in Mec1 activation |
703440 |
| 2.1.1.360 | malfunction |
transcriptionally silent telomeric variant surface glycoproteins become partially derepressed when DOT1B is deleted, whereas nontelomeric loci are unaffected |
-, 706402 |
| 2.1.1.360 | physiological function |
Dot1 and histone H3(K79) methylation are required for global genomic repair in both nucleosomal core regions and internucleosomal linker DNA but the enzyme is entirely dispensable for transcription coupled repair |
719926 |
| 2.1.1.360 | physiological function |
Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres, Dot1 contributes to checkpoint activation in response to low levels of telomere uncapping but is not essential with high levels of uncapping, Rad9 contributes to DNA damage metabolism because Rad9 inhibits the accumulation of single stranded DNA at uncapped telomeres |
703440 |
| 2.1.1.360 | physiological function |
Dot1 is required for efficient sister chromatid recombination, Dot1 promotes DNA double-strand break-induced loading of cohesin onto chromatin |
703872 |
