EC Number   |
General Information |
Reference |
|---|
   1.6.2.2 | evolution |
CyB5R is a member of the NAD(P)H-ferredoxin reductase (FNR) enzyme superfamily, phylogenetic analysis |
724801 |
| 1.6.2.2 | malfunction |
autosomal cytochrome b5 reductase gene deficiency manifests with the accumulation of oxidized Fe+3 and recessive congenital methemoglobinemia in humans. Diseases related to CyB5R dysfunctions, overviews |
724801 |
| 1.6.2.2 | malfunction |
autosomal cytochrome b5 reductase gene deficiency manifests with the accumulation of oxidized Fe3+ and recessive congenital methemoglobinemia in humans |
742321 |
| 1.6.2.2 | malfunction |
congenital methemoglobinemia due to deficiency of NADH-cytochrome b5 reductase is an autosomal recessive disorder characterized by life long cyanosis |
713187 |
| 1.6.2.2 | malfunction |
recessive congenital methaemoglobinaemia is caused by a deficiency of NADH-cytochrome b5 reductase |
741542 |
| 1.6.2.2 | malfunction |
the cytochrome b5/cytochrome b5 reductase system is a viable reductant for cytoglobin in vivo |
741940 |
| 1.6.2.2 | malfunction |
the enzyme is required for desaturation to biosynthesize polyunsaturated fatty acids |
741995 |
| 1.6.2.2 | malfunction |
the progeny of plants heterozygous for the cbr1-2 allele segregate 6% homozygous mutants, while cbr1-3 and cbr1-4 heterozygotes segregate 1:1 heterozygous:wild-type, indicating a gametophyte defect. Homozygous cbr1-2 seeds are deformed and required Suc for successful germination and seedling establishment. Vegetative growth of cbr1-2 plants was relatively normal, and they produced abundant flowers, but very few seeds. The pollen produced in cbr1-2 anthers is viable, but when germinated on cbr1-2 or wild-type stigmas, most of the resulting pollen tubes do not extend into the transmitting tract, resulting in a very low frequency of fertilization, phenotype, overview |
726166 |
| 1.6.2.2 | metabolism |
2e- transfer from NADH to the enzyme CyB5R, to FAD, followed by reduction of 2 CyB5 and electron transfer to desaturase, CyP450 or methemoglobin |
724801 |
| 1.6.2.2 | metabolism |
an increase of cytochrome b5 reductase flavin autofluorescence is observed in the presence of cytochrome b5. A dissociation constant value between proteins of 0.5 microM and a 1:1 stoichiometry for the complex formation are calculated. A 30 mV negative shift of cytochrome b5 reductase redox potential in presence of cytochrome b5 is observed |
764211 |
