EC Number   |
General Information |
Reference |
|---|
  1.1.1.431 | evolution |
D-xylose reductase is a member of the aldo-keto reductase family. Its catalytic mechanism is likely conserved in other AKRs that contain these amino acids. Expression profiles for D-xylose reductase xyrA, D-xylose reductase xyrB and L-arabinose reductase larA from Aspergillus niger, overview |
760777 |
| 1.1.1.431 | evolution |
phylogenetic tree analysis, overview |
-, 762450 |
| 1.1.1.431 | evolution |
the xylose reductase (XR) belongs to the AKR2 family xylose reductase of aldo-keto reductase (AKR) superfamily |
761066 |
| 1.1.1.431 | malfunction |
alteration in both secondary and tertiary structures cause enzyme deactivation in acidic pH, while increased deactivation rates at alkaline pH are attributed to the variation of tertiary structure over time |
-, 761017 |
| 1.1.1.431 | malfunction |
expression of gene xyrB is strongly reduced in the xlnR deletion strain on D-xylose and in the araR deletion strain on L-arabinose, indicating control of its expression by both regulators |
760777 |
| 1.1.1.431 | metabolism |
biosynthesis of xylitol can be achieved from two distinctive routes, one occurs via the activity of NADPH-dependent xylose reductase (XR), reducing xylose directly into xylitol. The other one proceeds via formation of the intermediate xylulose through xylose isomerase (XI, EC 5.3.1.5) followed by NADH-dependent reduction via the xylitol dehydrogenase (XDH, EC 1.1.1.9). Both of the metabolic routes originate from xylose dissimilation and can lead to formation of xylulose-5-phosphtate, the entrance point of pentose phosphate pathway |
760768 |
| 1.1.1.431 | metabolism |
D-xylose reductase is involved in D-xylose and L-arabinose conversion through the pentose catabolic pathway (PCP) in fungi |
760777 |
| 1.1.1.431 | metabolism |
derivatives of D-xylose and D-glucose, in which the hydroxy groups at C-5, and C-5 and C-6 are replaced by fluorine, hydrogen and azide are reduced with up to 3000fold increased catalytic efficiencies. Azide introduced at C-5 or C-6 destabilizes the transition state of reduction of the corresponding hydrogen-substituted aldoses by approx. 4 kJ/mol |
764095 |
| 1.1.1.431 | metabolism |
enzyme XR is the first enzyme in the xylose utilization pathway. Debaryomyces nepalensis, a nonpathogenic Saccharomycetes yeast can utilize both hexose and pentose sugars to produce polyols. DnXR is a key metabolic enzyme in the D-xylose utilization pathway |
761066 |
| 1.1.1.431 | metabolism |
ordered mechanism in which coenzyme binds first and substrate second |
764945 |
