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EC Number	Expression	Commentary	Reference
6.3.4.3	down	the expression of MTHFD1L is significantly affected by the mTORC1-4EBP1-eIF4E axis	765861
6.3.4.3	up	MTHFD1L is transcriptionally activated by NRF2, a master regulator of redox homeostasis. MTHFD1L is a transcription target of nuclear factor (erythroid-derived 2)-like 2 (NRF2), a transcription factor that acts as the central regulator for redox homeostasis. NRF2 expression is tightly regulated by kelch-like ECH-associated protein 1 (KEAP1), a negative regulator that targets NRF2 for proteosomal degradation	765141

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Release 2023.1 (January 2023)