EC Number   |
Expression |
Reference |
|---|
   3.1.4.53 | down |
p53 inactivates isoform PDE4D by inducing the expression of miR-139-5p which directly binds to the target sequence at 3'-UTR of PDE4D mRNA |
750402 |
| 3.1.4.53 | more |
isoforms PDE1B, PDE1C, PDE2A, PDE4A, PDE4D, PDE5A, PDE7A, PDE8A, PDE8B, PDE10A, and PDE11A show an age-related increase or decrease in mRNA expression in at least 1 of the 4 brain regions examined (hippocampus, cortex, striatum, and cerebellum). mRNA expression of isoforms PDE1A, PDE3A, PDE3B, PDE4B, PDE7A, PDE7B, and PDE9A does not change with age |
729558 |
| 3.1.4.53 | up |
2fold increased PDE7B mRNA expression in chronic lymphocytic leukemia correlates with a 10fold higher expression of PDE7B protein and results in an increased contribution of PDE7 to total PDE activity |
713394 |
| 3.1.4.53 | up |
cpdA expression is positively regulated by cAMP-Vfr. cAMP-Vfr binds to the cpdA promoter region, suggesting that in vivo, cpdA transcription is directly activated by cAMP-Vfr |
712298 |
| 3.1.4.53 | up |
forskolin treatment alone is unable to stimulate mAKAP-bound PDE4D3 activity significantly in HEK-293 cells, whereas forskolin (0.05 mM) and okadaic acid (0.3 mM) treatment together synergistically increase PDE4D3 activity |
712415 |
| 3.1.4.53 | up |
isoform PDE1C expression is highly induced in neointimal smooth muscle cells of human coronary arteries |
750336 |
| 3.1.4.53 | up |
isoform PDE1C expression is low in contractile smooth muscle cells but drastically elevated in synthetic smooth muscle cells in vitro and in various mouse vascular injury models in vivo |
750336 |
| 3.1.4.53 | up |
isoform PDE4D7 doubles in activity after forskolin treatment |
750540 |
| 3.1.4.53 | up |
the cAMP-dependent transcription factor Vfr directly activates expression of cpdA in response to elevated intracellular cAMP |
712298 |
| 3.1.4.53 | up |
transcription factor Trps1 directly activates isoform Pde4d transcription |
750921 |
