EC Number   |
Expression |
Reference |
|---|
   1.2.1.36 | down |
ERK and p38 MAPK inhibitors PD98059 and SB203580 suppress GM-CSF-induced nuclear translocation of Sp1 and Aldh1a2 expression. CpG methylation in the Aldh1a2 promoter region inhibits Sp1-dependent Aldh1a2 promoter activation. Aldh1a2 transcription silencing by CpG methylation of the promoter region is not due to direct interference with Sp1 binding to the promoter region |
-, 743660 |
| 1.2.1.36 | down |
high retinoic acid levels inhibit Raldh1 gene expression by sequestering CCAAT/enhancer binding protein beta through its interaction to GADD153. A decrease in Raldh1 mRNA levels in the aryl hydrocarbon receptor-null liver relative to wild type mouse liver is observed |
711154 |
| 1.2.1.36 | down |
inflammation reduces ALDH1A1 mRNA in whole liver regardless of the level of vitamin A in the diet, while treatment with retinal reduces ALDH1A1 expression only in chow-fed rats. Acute inflammation rapidly downregulates ALDH1A1 expression in whole liver |
743375 |
| 1.2.1.36 | down |
levels of RALDH1 gene expression and protein production markedly decrease after 1-week treatment with 17beta-estradiol in male rats. Treatment of isolated anterior pituitary cells with 17beta-estradiol (0.00001-10 nM) decreases expression of RALDH1 mRNA in a dose-dependent manner (about 55% RALDH1 mRNA level remaining 6 h after treatment with 10 nM 17beta-estradiol). 17beta-Estradiol-induced suppression of RALDH1 expression is completely blocked by the estrogen receptor antagonist ICI 182, 780. The ERalpha-selective agonist propylpyrazole triol (10 nM) mimicks the effect of 17beta-estradiol on RALDH1 expression, but the ERbeta-selective agonist diarylpropionitrile (10 nM) does not |
711854 |
| 1.2.1.36 | down |
retinal dehydrogenase 5 is significantly downregulated in hepatocellular carcinoma tissues |
763150 |
| 1.2.1.36 | up |
acute inflammation rapidly increases the enzyme expression in periportal macrophages |
743375 |
| 1.2.1.36 | up |
enhanced activity and expression of RALDHs in liver of high-fat diet rats. High-fat diet feeding significantly up-regulates cytosolic RALDHs activity, 1.7fold and 2fold in the presence of NAD+ and NADP+, respectively |
-, 743142 |
| 1.2.1.36 | up |
granulocyte-macrophage colony-stimulating factor (GMCSF) potently induces RALDH2 expression in dendritic cells in an retinoic acid-dependent manner, and retinoic acid alone weakly induces the expression. Retinoic acid and GM-CSF coordinately induce retinal dehydrogenase 2 (RALDH2) expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells |
-, 743660 |
| 1.2.1.36 | up |
mRNA expression is upregulated by p53 (44.3fold) and p63gamma (16.3fold) by binding to the retSDR1 promoter in vivo |
724697 |
| 1.2.1.36 | up |
obesity and insulin resistance are associated with overexpression of retinaldehyde dehydrogenase 1. High-fat-diet-feeding significantly induces the activity and expression of RALDH1 protein |
762688 |
