EC Number   |
Expression |
Reference |
|---|
    1.14.14.1 | down |
in hepatocyte cultures, treated with 0.05 mM Andrographis paniculata extract and Andrographolide, CYP2E1 is not significantly decreased (by 30%) |
703164 |
| 1.14.14.1 | down |
in hepatocyte cultures, treatment with 0.05 mM Andrographis paniculata extract and Andrographolide results in a 50% decrease in CYP3A1 expression and activity |
703164 |
| 1.14.14.1 | down |
in hepatocyte cultures, treatment with 0.05 mM Andrographis paniculata extract and Andrographolide results in a 60% decrease in CYP1A2 expression and activity |
703164 |
| 1.14.14.1 | down |
in hepatocyte cultures, treatment with 0.05 mM Andrographis paniculata extract and Andrographolide results in a 60% decrease in CYP2C11 expression and activity. After in vivo administration, Andrographis paniculata extract at dose levels of 0.5 g/kg/day (i.e. 5 mg/kg/day Andrographolide equivalents) and at 2.5 g/kg/day (i.e. 25 mg/kg/day Andrographolide equivalents) and Andrographolide at dose levels of 5 and 25 mg/kg/day significantly decrease CYP2C11 activity |
703164 |
| 1.14.14.1 | down |
in hepatocyte cultures, treatment with 0.05 mM Andrographis paniculata extract results in a slight decrease of CYP1A2 (30%) enzymatic activities |
703164 |
| 1.14.14.1 | down |
in hepatocyte cultures, treatment with 0.05 mM Andrographis paniculata extract results in a slight decrease of CYP2E1 (20%) enzymatic activities, whereas CYP2C9- and CYP3A4-dependent monooxygenase activities are significantly decreased by 40% and 60%, respectively. Andrographolide causes a 30% decrease in CYP2C9- and CYP3A4-dependent monooxygenase activities, which is not significant |
703164 |
| 1.14.14.1 | down |
mutations in NADPH-P450 reductase, identified in patients with disordered steroidogenesis/Antley-Bixler syndrome, reduce CYP3A4 activity. NADPH-P450 reductase mutants Y181D, A457H, Y459H, V492E and R616X loose more than 99% of CYP3A4 activity, while NADPH-P450 reductase mutations A287P, C569Y and V608F loose 60-85% activity |
711114 |
| 1.14.14.1 | down |
resveratrol inhibits dioxin-induced expression of CYP1A1, CYP1A2 and CYP1B1 by directly or indirectly inhibiting the recruitment of the transcription factors aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator to the xenobiotic response elements of the corresponding genes |
706841 |
| 1.14.14.1 | down |
some P450 genes are downregulated in nutrient-rich malt extract cultures (2.15- to 13.36fold) or in defined low-nitrogen cultures (2.02- to 4.15fold) in response to nonylphenol |
-, 701804 |
| 1.14.14.1 | up |
0.0001 mM dioxin treatment for 24, 48, and 72 h induces CYP1A1, CYP1A2 and CYP1B1 mRNA levels |
706841 |
