EC Number   |
Expression |
Reference |
|---|
   1.14.13.8 | down |
analysis of the diurnal rhythms of Fmo5 expression and activity in mouse liver and of the potential roles of clock genes (Bmal1, Rev-erba, and E4bp4) in the generation of diurnal rhythms. Fmo5 mRNA and protein show robust diurnal rhythms, with peak values at zeitgeber time (ZT) 10/14 and trough values at ZT2/22 in mouse liver. Bmal1 (a known Rev-erba activator) activates Fmo5 transcription via direct binding to an E-box (21822/21816 bp) in the promoter, whereas E4bp4 (a known Rev-erba target gene) inhibits Fmo5 transcription by binding to two D-boxes (21726/21718 and 2804/2796 bp). In conclusion, circadian clock genes control diurnal expression of Fmo5 through transcriptional actions on E-box and D-box cis-elements |
-, 764557 |
| 1.14.13.8 | down |
bacterial lipopolysaccharides lead to enzyme downregulation in the liver, as well as posttranslationally S-nitrosylation by nitric oxide |
703320 |
| 1.14.13.8 | down |
downregulation of FMO1 and FMO3 by glucocorticoids and progesterone |
703320 |
| 1.14.13.8 | down |
in female mice, testosterone plays a role in negative FMO regulation |
703320 |
| 1.14.13.8 | down |
isozyme expressions, especially of Fmo3, are downregulated by lipopolysaccharides or infection with Citrobacter rodentium in inflammation female C3H/HeOuJ mouse models, which is independent of Toll-like receptor 4, TLR4, overview |
703417 |
| 1.14.13.8 | more |
isozyme Fmo1 is not affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure or castration in contrast to other Fmo isozymes, overview |
-, 711162 |
| 1.14.13.8 | more |
no induction of FMO3 in Hepa-1 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin, DMSO, beta-naphthoflavon, 3,3',4,4',5-pentachlorobiphenyl, butylated hydroxyanisole, menadione, sulphoraphane, and tert-butylhydroquinone |
713541 |
| 1.14.13.8 | up |
8fold induction of FMO3 in liver by 3-methylcholanthrene. In Hepa-1 cells, 3-methylcholanthrene and benzo[a]pyrene induce FMO3 mRNA by about 30fold in an aryl hydrocarbon receptor-dependent manner. Aryl hydrocarbon receptor, AHR, dependent induction of FMO mRNAs in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin, but the potent AHR agonist, TCDD, does not induce FMO3 mRNA in Hepa-1 cells. Mechanism of FMO3 mRNA induction, overview |
713541 |
| 1.14.13.8 | up |
analysis of the diurnal rhythms of Fmo5 expression and activity in mouse liver and of the potential roles of clock genes (Bmal1, Rev-erba, and E4bp4) in the generation of diurnal rhythms. Fmo5 mRNA and protein show robust diurnal rhythms, with peak values at zeitgeber time (ZT) 10/14 and trough values at ZT2/22 in mouse liver. Bmal1 (a known Rev-erba activator) activates Fmo5 transcription via direct binding to an E-box (21822/21816 bp) in the promoter, whereas E4bp4 (a known Rev-erba target gene) inhibits Fmo5 transcription by binding to two D-boxes (21726/21718 and 2804/2796 bp). In conclusion, circadian clock genes control diurnal expression of Fmo5 through transcriptional actions on E-box and D-box cis-elements |
-, 764557 |
| 1.14.13.8 | up |
FMO3 expression in response to administration of the anti-schizophrenia drug olanzapine, allele frequencies and phenotypes, overview |
703424 |
