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EC Number Application Commentary Reference
Show all pathways known for 6.3.4.3Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.3drug development MTHFD1L overexpression is closely associated with aggressive clinicopathological features of hepatocellular carcinoma (HCC) including the presence of tumor microsatellite formation, venous invasion, and more advanced tumor stages. The enzyme MTHFD1L is a potential target in cancer therapy. Inhibition of the folate cycle sensitizes HCC cells to sorafenib treatment in vitro and in vivo 765141
Show all pathways known for 6.3.4.3Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.3medicine MTHFD1L may be involved in OSCC progression via the c-MYC gene and p53 signaling and may serve as a target and orientation for tumor therapy 765861
Show all pathways known for 6.3.4.3Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.3pharmacology the enzyme might be a target for colorectal cancer therapy 660866
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