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EC Number Application Commentary Reference
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1analysis colorimetric assay method to measure acetyl-CoA synthetase activity 674377
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1medicine acetyl-CoA synthetase appears to be important in acetate uptake and acetate-dependent lipid synthesis for the growth of cancer cells with a low-glycolysis phenotype 705292
Show all pathways known for 6.2.1.1Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.1medicine cells express higher levels of cytosolic acetyl-CoA synthetase ACSS2 under hypoxia than normoxia. Knockdown of ACSS2 by RNA interference in tumor cells enhances tumor cell death under long-term hypoxia in vitro. The ACSS2 suppression slows tumor growth in vivo. Tumor cells excrete acetate and the quantity increases under hypoxia, the pattern of acetate excretion follows the expression pattern of ACSS2. The ACSS2 knockdown leads to a corresponding reduction in the acetate excretion in tumor cells 703038
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