EC Number   |
Application |
Reference |
|---|
    5.3.1.1 | analysis |
specific polymerase chain reaction protocols used to determine the prevalence of toxigenic Clostridium difficile in Vhembe, South Africa. The study confirms the usefulness of PCR methodologies in the detection of toxigenic Clostridium difficile and suggests that Clostridium difficile is responsible for a small, but underappreciated, proportion of diarrheal cases in the region |
690389 |
| 5.3.1.1 | analysis |
systematic mutagenesis method to find critical residues for certain physico-chemical properties of a protein. The method is a shorter alternative to random mutagenesis, saturation mutagenesis or directed evolution to find multiple amino acids critical for certain properties of proteins |
748803 |
| 5.3.1.1 | biofuel production |
proteome analysis as well as enzyme assays performed in cell-free extracts demonstrates that glycerol is degraded via glyceraldehyde-3-phosphate, which is further metabolized through the lower part of glycolysis leading to formation of mainly ethanol and hydrogen. Fermentation of glycerol to ethanol and hydrogen by this bacterium represents a remarkable option to add value to the biodiesel industries by utilization of surplus glycerol |
748573 |
| 5.3.1.1 | diagnostics |
triosephosphate isomerase is a serum marker for human lung squamous cell carcinoma |
703037 |
| 5.3.1.1 | medicine |
67% of 39 patients suffering from adverse reactions to lychee show allergic reactions resp. IgE binding of their sera to enzyme protein |
679944 |
| 5.3.1.1 | medicine |
analysis of key aspects of triosephosphate isomerase deficiency glycolytic enzymopathy pathogenesis identified using the TPIsugarkill mutation M80T, a Drosophila model of the human disease deficiency. Mutant protein is expressed, capable of forming a homodimer, and is functional. However, the mutant protein is degraded by the 20S proteasome core leading to loss-of-function pathogenesis |
692508 |
| 5.3.1.1 | medicine |
evaluation of the ability of naive monocyte-derived dendritic cells to sensitize peripheral blood mononuclear cells to the Schistosoma vaccine candidate MAP4 using a priming in vitro assay. MAP4 is a multiple antigen peptide containing B- and T-cell epitopes derived from the enzyme triose phosphate isomerase. Cytokine production from activated MAP4 priming in vitro cells is predominantly Th1-like, consisting mainly of IFN-gamma. Naive donor dendritic cells, sensitized with MAP4, thus are able to prime and clonally expand MAP4-specific T cells towards a Th1-type response |
695125 |
| 5.3.1.1 | medicine |
in drug-resistant SGC7901 cells induced by vincristine sulfate, triosephosphate isomerase is downregulated.The sensitivity of TPI-SGC7901/VCR cells to adriamycin, vincristine, 5-fluorouracil and cis-dichlorodiamine platinum, as well as the accumulation and retention to adriamycin, are significantly increased when compared to their control cell lines |
693299 |
| 5.3.1.1 | medicine |
specific polymerase chain reaction protocols used to determine the prevalence of toxigenic Clostridium difficile in Vhembe, South Africa. The study confirms the usefulness of PCR methodologies in the detection of toxigenic Clostridium difficile and suggests that Clostridium difficile is responsible for a small, but underappreciated, proportion of diarrheal cases in the region |
690389 |
| 5.3.1.1 | medicine |
TPI1 expression is greatly decreased in clinical hepatocellular carcinoma samples, positively correlated with overall survival, and negatively associated with histological differentiation, tumor size and organ metastasis. Forced expression of TPI1 in hepatocellular carcinoma cells inhibits cell growth, migration, and invasion in vitro. Knockdown of TPI1 by shRNA promotes cell growth, migration and invasion. Overexpression of TPI1 leads to slowed tumor growth and decreased tumor weight in vivo. Cell cycle arrest is induced by TPI1 overexpression |
746982 |
