   3.4.14.10 | medicine |
isoform TPPII can regulate sperm maturation by modulating intracellular Ca2+ stores via the type 3 ryanodine receptor. Tripeptidyl peptidase II antagonists strongly activate the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. In the absence of Ca2+, TPPII antagonists elevate the intracellular Ca2+ levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca2+ can be blocked by the inhibitors of ryanodine receptors which are the main intracellular Ca2+ channels responsible for releasing stored Ca2+ |
732731 |
