EC Number   |
Application |
Reference |
|---|
    3.1.1.2 | analysis |
description of an easy and non-toxic method for large scale phenotyping and activity quantitation of arylesterase |
35215 |
| 3.1.1.2 | analysis |
quantification of arylesterase activity in routine clinical studies by monitoring the formation of acetic acid, upon the hydrolysis of phenyl acetate, using 10 microl of sample. The method accuracy is higher than 90% and intra-assay and inter-assay precisions are 96% and 95%, respectively. The procedure is suitable for use in human serum and heparinized plasma samples, while ethylenediaminetetra-acetic acid containing samples should be avoided |
728957 |
| 3.1.1.2 | analysis |
the enzyme has the potential to be used as a catalytic bioscavenger of nerve agents. Insect production of the enzyme may provide a source for both in vitro enzymatic and crystallographic studies and in vivo stability and anti-nerve agent efficacy testing |
708095 |
| 3.1.1.2 | analysis |
use of 9-(4-chlorophenyloxycarbonyl)-10-methylacridinium triflate as a substrate for serum PON arylesterase activity assay. The apparent Km value of a serum sample for the substrate is 85 nmol/l, close to the Km value of recombinant human isoform PON1. Recombinant human PON1 in presence of CaCl2 shows at least 7.8 times selectivity over acetylcholinesterase and lipases. The method allows reliable, cost-saving, and specific determination in a buffer of physiological pH |
730985 |
| 3.1.1.2 | drug development |
resistance of strains to permethrin is associated with elevated levels of enzyme |
670486 |
| 3.1.1.2 | medicine |
aryl esterase activitiy correlates positively with total antioxidant status, high density lipoprotein and apolipoprotein A-I |
695124 |
| 3.1.1.2 | medicine |
baseline and stimulated ARE activity is significantly lower in patients with chronic liver disease than in controls, serum ARE activity can be a suitable biomarker for the evaluation of the presence and severity of chronic liver damage |
692695 |
| 3.1.1.2 | medicine |
biologic monitoring for AREase status among pesticide handlers may be warranted to identify individuals who are at particularly high risk of organophosphate-related health effect |
703470 |
| 3.1.1.2 | medicine |
both PON1 bioavailability and catalytic activity are decreased in children with autism spectrum disorders |
693321 |
| 3.1.1.2 | medicine |
diminished paraoxonase and arylesterase activity is associated with particular stage, grade and CA-125 level of ovarian cancer |
692541 |
