EC Number   |
Application |
Reference |
|---|
    2.8.1.1 | analysis |
detection method for cyanide based on in-capillary enzymic reaction. Method shows a linear detection range from 0.015 to 0.5 mM with a detection limit of 0.003 mM and a limit of quantitation of 0.09 mM. The method is rapid, simple and can easily be automated |
675044 |
| 2.8.1.1 | medicine |
adult rats on high fructose diet have 56% decrease in thiosulfate-dithiol sulfurtransferase activity, 35% decrease in cystathionine beta synthase and 48% decrease in cystathionine gamma synthase activity, compared to a standard diet group. Aged rats on high fructose diet have lower activities of all three enzymes versus aged rats on standard diet. Increased activities of all H2S-related enzymes are oberved during induction of acute water immersion restraint stress. In adult rats exposed to stress on high fructose diet and treatment by NaHS, 1.8 times increased activities of cystathionine beta synthase, 1.3 times increased activities of cystathionine gamma synthase, and 69% increased activities of thiosulfate-dithiol sulfurtransferase are seen over adult rats with vehicle. Rats fed by high fructose diet have higher levels of the oxidative index than animals fed by standard diet. The pretreatment by H2S donors NaHS and 4-carbamothioylphenyl 2-(acetyloxy)benzoate in aged rats reduces the oxidative index levels and correlate with thiosulfate-dithiol sulfurtransferase activity |
761166 |
| 2.8.1.1 | medicine |
CysA2 interacts with pulmonary cells, and it is capable to activate macrophages and dendritic cells |
-, 762459 |
| 2.8.1.1 | medicine |
enzyme mRNA expression in adipose tissue correlates positively with insulin sensitivity in adipose tissue and negatively with fat mass. Genetic enzyme identification as a beneficial regulator of adipocyte mitochondrial function has therapeutic significance for individuals with type 2 diabetes |
739155 |
| 2.8.1.1 | medicine |
in advanced colon cancers, expression of both thiosulfate sulfurtransferase and mercaptopyruvate sulfurtransferase is markedly reduced, the disease progression correlating with decrease in expression. In human colon cancer cell line HT-29, enzyme activity and expression are significantly increased by butyrate and by histone deacetylaseinhibition. Use of decrease in enzyme expression as a tumor marker for colorectal cancer |
671241 |
| 2.8.1.1 | medicine |
low expression of thiosulfate sulfurtransferase predicts mortality in hemodialysis patients |
724781 |
| 2.8.1.1 | medicine |
thiosulfate sulfurtransferase does not metabolize sulfide. The rate limiting step in sulfide detoxification is oxidation by a sulfide oxidase to thiosulfate, therefor the use of thiosulfate sulfurtransferase activity to determine the rate that colonic mucosa detoxifies sulfide is inappropriate |
673274 |
| 2.8.1.1 | pharmacology |
target for developing a tuberculosis drug |
-, 690262 |
