EC Number   |
Application |
Reference |
|---|
   2.4.1.152 | analysis |
synthesis of fluorescein-isothiocyanate-labeled and carboxyfluorescein-labeled NDP-beta-L-fucose derivatives, and application in labeling of different glycoproteins with the aid of fucosyltransferases. The fluorescein-isothiocyanate-labeled fucose is the best of these substrates, and the bacterial enzyme FucT tolerates the fluorescent substrates better than human fucosyltransferases |
756446 |
| 2.4.1.152 | biotechnology |
a baculoviral expression system of FucT-IX appears to be a promising strategy for overproduction as compared to overproduction in Escherichia coli or mammalian cells |
703540 |
| 2.4.1.152 | drug development |
development of a high-throughput screening system for identification of FucT-VII inhibitors, which could have anti-inflammatory or anti-metastatic potential, utilizing scintillation proximity assay with fetuin-coated beads, overview |
660698 |
| 2.4.1.152 | drug development |
fucosyltransferase VII is a very promising drug target for treatment of inflammatory skin diseases |
690403 |
| 2.4.1.152 | drug development |
FucT-VII and the E- and P-selectin pathways may prove a fruitful therapeutic target in the prevention or treatment of atherosclerosis |
701615 |
| 2.4.1.152 | medicine |
FT-IV and FT-VII are both important contributors to selectin-dependent eosinophil recruitment to the skin and may represent therapeutic targets in which eosinophil recruitment contributes to pathophysiology |
671207 |
| 2.4.1.152 | medicine |
fucosyltransferase IV overexpression promotes cell proliferation, increases the expression of proliferating cell nuclear antigen and augments Lewis Y expression to trigger neoplastic cell proliferation, fucosyltransferase IV may serve as a potential therapeutic target for the treatment of Lewis Y-positive epithelial cancers |
687115 |
| 2.4.1.152 | medicine |
FucT-VII is critical for the recruitment of Th1 cells in inflamed brain microcirculation |
675196 |
| 2.4.1.152 | medicine |
FUT7 mRNA is highly over-expressed at the site of inflammation and in tumorigenesis |
667231 |
| 2.4.1.152 | medicine |
granzyme B-induced caspase 3-activation leads to up-regulation of FUT4 and FUT9 mRNA expression, which increases the surface expression of Lewis X and Y antigens |
672496 |
