EC Number   |
Application |
Reference |
|---|
    2.1.2.1 | analysis |
molecular dynamics simulations and interaction energy analysis for compounds designed as potential selective inhibitors of Plasmodium falciparum SHMT based on the conformational and dynamics differences observed between the residues Asp146 and Glu137 in the active sites of human SHMT and Plasmodium falciparum SHMT, respectively |
674993 |
| 2.1.2.1 | analysis |
protein sequence of the two isoforms, the short form SHMT-S and the long form SHMT-L, show 59% identity |
675874 |
| 2.1.2.1 | analysis |
SHMT1 is a zinc-inducible gene, provides first mechanism for the regulation of folate-mediated one-carbon metabolism by zinc |
674506 |
| 2.1.2.1 | biotechnology |
the AlkS/PalkB-expression system is shown as an efficient tool for the production of recombinant serine hydroxymethyltransferase in Escherichia coli fed-batch fermentations |
685708 |
| 2.1.2.1 | degradation |
essential for one-carbon metabolism |
676615 |
| 2.1.2.1 | drug development |
the enzyme might be a a key target for the development of chemotherapic agents |
736727 |
| 2.1.2.1 | drug development |
the enzyme represents a potential target for chemotherapeutics |
-, 737188 |
| 2.1.2.1 | drug development |
the human enzyme is a potential target for cancer treatment |
736084 |
| 2.1.2.1 | medicine |
animal model for drug screening of SHMT |
-, 676954 |
| 2.1.2.1 | medicine |
drug target in Leishmania |
-, 676982 |
