EC Number   |
Recommended Name |
Application |
|---|
    7.1.1.9 | cytochrome-c oxidase |
more |
100% homology among cox1 sequences from morphotype 1 (females presenting caudal tips smooth without spines) and morphotype 2 (females presenting caudal tips smooth with spines) of Filaria martis collected from beech martens, thus indicating that the shape of female posterior edge may vary among specimens |
| 2.7.13.3 | histidine kinase |
more |
15 of the 30 known Escherichia coli histidine kinases contain a single HAMP domain, has an important role in signal transduction |
| 4.6.1.1 | adenylate cyclase |
more |
15 putative AC genes present |
| 3.2.1.15 | endo-polygalacturonase |
more |
18 polygalacturonase genes identified in strain 99-880. Ancestral form of polygalacturonase in fungi is endolytic and exolytic function evolved later |
| 3.4.21.61 | Kexin |
more |
1G08 fragment antigen binding represents a useful new tool for delineating the mechanism of PCSK9 uptake and low density lipoprotein receptor degradation |
| 2.7.11.24 | mitogen-activated protein kinase |
more |
21 putative poplar MAPK genes identified and located within the poplar genome, distributed over 12 of the 19 poplar chromosomes |
| 1.1.1.31 | 3-hydroxyisobutyrate dehydrogenase |
more |
3-HIBADH may play a role in biosynthesis of 3-hydroxypropionate as a biological source |
| 1.3.99.4 | 3-oxosteroid 1-dehydrogenase |
more |
3-oxosteroid DELAT1-dehydrogenases are of particular interest for the etiology of some infectious diseases, for the production of starting materials for the pharmaceutical industry, and for environmental bioremediation applications |
| 3.4.21.B21 | trepolisin |
more |
43000 protein involved in the stabilization of the dentilisn protein |
| 2.7.13.3 | histidine kinase |
more |
44 genes for Hiks on the chromosome, Hik34 might act as a negative regulator of the expression of heat-shock genes during normal growth. Hik33 is a cold sensor, participates in the positive regulation of the expression of more than 60% of the cold-inducible genes, is also involved in the perception of hyperosmotic stress and salt stress and transduction of the signals, findings cannot be explained by the current model of two-component systems |
| 1.3.1.3 | DELTA4-3-oxosteroid 5beta-reductase |
more |
5beta-POR is highly conserved within the genus Digitalis and the respective genes and proteins share considerable homology to putative progesterone reductases from other plant species |
| 3.7.1.6 | acetylpyruvate hydrolase |
more |
75fold increased productivity of the enzyme by media optimization, optimal glucose, yeast extract and (NH4)2SO4 concentrations produce 7fold more biomass than the initial medium, optimization also by determining the optimal time of feed and amount of orcinol |
| 1.2.3.1 | aldehyde oxidase |
more |
96% amino acid identity with those of human enzyme. Two forms of aldehyde oxidase in monkey are the expression products by a single gene due to possibly existence of two aldehyde oxidase isoforms or two active sites in a single enzyme |
| 2.1.1.9 | thiol S-methyltransferase |
more |
a few changes in key residues are sufficient to convert an OMT into a S-methyltransferase |
| 1.4.3.2 | L-amino-acid oxidase |
more |
a helical domain is exclusively responsible for the unusual dimerisation mode of the enzyme and is not found in other members of the family so far. Most groups present at the active site are involved in substrate recognition, binding and fixation, i.e. they direct the trajectory of the interacting orbitals. In this mode of catalysis orbital steering/interactions are the predominant factors for the chemical step(s). A mirrorsymmetrical relationship between the two substrate-binding sites of D and L-amino acid oxidases is observed which facilitates enantiomeric selectivity while preserving a common arrangement of the residues in the active site |
| 3.2.1.102 | blood-group-substance endo-1,4-beta-galactosidase |
more |
a highly sensitive fluorescence-based high-throughput assay for both endo-beta-galactosidase and activity specific for the oligosaccharide structure of the blood group A antigen is developed. The potential to use this assay is demostrated to screen the expressed gene products of metagenomic libraries in the search for efficient blood group antigen-cleaving enzymes |
| 2.7.13.3 | histidine kinase |
more |
a LOV domain at the N-terminus, followed by a PAS domain in the intervening sequence, and a histidine kinase at the C-terminus |
| 3.4.21.5 | thrombin |
more |
a modified in situ proteolysis approach is applied to specifically remove the His tag by thrombin cleavage during crystallization screening trials. This improves the morphology and diffraction quality of the crystals and allowes the acquisition of high-resolution diffraction data and structure solution |
| 1.8.1.4 | dihydrolipoyl dehydrogenase |
more |
a mutation in LPD leads to a pyruvate dehydrogenase complex that is less sensitive to inhibition by NADH, allowing the enzyme to function in an anaerobic culture, which changes the fermentation profile of the mutant. Presence and functional activity of such an NADH-insensitive pyruvate dehydrogenase may have significant unexplored physiological and biotechnological applications |
| 3.1.22.1 | deoxyribonuclease II |
more |
a nuclear export signal on LEI involved in the control of LEI/L-DNase II nuclearization in healthy cells |
| 2.1.1.28 | phenylethanolamine N-methyltransferase |
more |
a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits a minimal affinity for the alpha-adrenoceptor, would be a useful pharmacological tool for clearly defining the connection between central epinephrine concentrations and blood pressure. |
| 2.1.1.28 | phenylethanolamine N-methyltransferase |
more |
a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits minimal affinity for the alpha2-adrenoceptor and is able to cross the brain-blood-barrier, would be a useful pharmacological tool for defining the role of epinephrine in the central nervous systhem. |
| 3.1.6.12 | N-acetylgalactosamine-4-sulfatase |
more |
a relatively high rate of immunotolerance towards recombinant human N-acetylgalactosamine-4-sulfatase can be achieved in MPS-VI cats with a shortcourse tolerisation regimen ultimately permitting removal of lysosomal storage within the dura mater with the use of intrathecal therapy |
| 2.7.11.24 | mitogen-activated protein kinase |
more |
a role for active Hog1 in maintaining signaling specificity under conditions of persistently high external osmolarity |
| 3.4.21.108 | HtrA2 peptidase |
more |
a role for Omi-mediated processing of WTS in negative regulation of cell cycle progression at interphase. Omi protease is not necessarily required for cell death |
| 3.4.22.B1 | vignain |
more |
a role of Cyp15a cysteine protease in germination and stress adaption and also in nodule organogenesis and function |
| 1.1.3.7 | aryl-alcohol oxidase |
more |
a two-enzyme system comprising a dye decolorizing peroxidase (DyP, EC 1.11.1.19) from Mycetinis scorodonius and the Pleurotus sapidus AAO enzyme is successfully employed to bleach the anthraquinone dye Reactive Blue 5. The aryl-alcohol oxidase provides the required H2O2 |
| 3.4.21.79 | granzyme B |
more |
ability of gzmH to cleave host proteins involved in essential viral functions provides a novel mechanism by which granzymes can mediate direct antiviral activities |
| 3.4.21.62 | Subtilisin |
more |
ability of poly(ethylene)-glycol-modification to systematically modulate the structural dynamics of subtilisin Carlsberg in 1,4-dioxane. At increasing levels of modification the enzyme becomes more flexible, thus catalytically more active. In contrast, increasing the enzyme flexibility through poly(ethylene)-glycol-modification reduces the enzyme enantioselectivity |
| 3.2.1.91 | cellulose 1,4-beta-cellobiosidase (non-reducing end) |
more |
ability to amplify a key fungal cellobiohydrolase I gene involved in plant litter decomposition has the potential to unlock the identity and dynamics of the cellulolytic fungal community in situ |
| 3.2.1.176 | cellulose 1,4-beta-cellobiosidase (reducing end) |
more |
ability to amplify a key fungal cellobiohydrolase I gene involved in plant litter decomposition has the potential to unlock the identity and dynamics of the cellulolytic fungal community in situ |
| 3.4.24.32 | beta-Lytic metalloendopeptidase |
more |
ability to lyse Arthrobacter globiformis, Micrococcus luteus and Staphylococcus aureus cells, inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent |
| 3.4.24.32 | beta-Lytic metalloendopeptidase |
more |
ability to lyse Micrococcus luteus and Staphylococcus aureus cells |
| 4.6.1.1 | adenylate cyclase |
more |
AC8 acts as a low-pass filter for high-frequency Ca2+ events, enhancing the regulatory options available to this signalling pathway |
| 4.6.1.1 | adenylate cyclase |
more |
ACA has the same architecture as mammalian membrane-bound ACs, is essential for reacting to and production of cAMP. ACG is essential for germination. ACB is required for terminal maturation of spores |
| 3.1.1.7 | acetylcholinesterase |
more |
AChE from the juvenile Colossoma macropomum brain can be used as an alternative biocomponent of organophosphorus and carbamate biosensors in routine pesticide screening in the environment |
| 4.6.1.1 | adenylate cyclase |
more |
ACIII is a marker for primary cilia throughout many regions of the adult mouse brain |
| 1.3.3.6 | acyl-CoA oxidase |
more |
ACOX1 alternative splicing isoforms play a key conserved role in the vertebrate fatty acid metabolism, tissue-specific modulation of ACOX1 activity by exchanging exon 3 duplicated isoforms containing amino acid sequences that are potentially implicated in fatty acyl chain specificity |
| 4.6.1.24 | ribonuclease T1 |
more |
acquisition of male, female or bisexual sterility by transgenic plants with the help of barnase. The enzyme is useful in medical research, overview |
| 4.6.1.1 | adenylate cyclase |
more |
ACT enhances the adhesive functions of filamentous haemagglutinin and modifies the performance of the filamentous haemagglutinin heparin-inhibitable carbohydrate binding site |
| 4.6.1.1 | adenylate cyclase |
more |
activation of the HCO3-/sAC transduction pathway enhances both cftr gene and CFTR protein expression and appears to be a physiological mechanism whereby the cell adapts to variations in extracellular HCO3- concentration |
| 1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) |
more |
activation of the translational regulators by leucine is partly regulated by the activity of BCKDH complex |
| 5.6.1.6 | channel-conductance-controlling ATPase |
more |
active scorpion venom of Leirus quinquestriatus hebraeus may be used as a tool to study the conformational changes that occur during CFTR gating |
| 1.3.8.7 | medium-chain acyl-CoA dehydrogenase |
more |
acyl-CoA dehydrogenase LipB is involved in the introduction of the unusual Dcis3 double bond into the acyl residue of friulimicin |
| 3.4.24.14 | procollagen N-endopeptidase |
more |
ADAMTS2 diplays procollagen III N-endopeptidase activity, proteolytic processing of ADAMTS2 may generate fragments displaying specifically either procollagen I/II or procollagen III N-endopeptidase acitvity |
| 3.1.11.5 | exodeoxyribonuclease V |
more |
AddA mutants that cannot bind or hydrolyze ATP are completely defective for DNA recombination |
| 5.3.1.4 | L-arabinose isomerase |
more |
additionally, D-tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick |
| 5.3.1.4 | L-arabinose isomerase |
more |
additionally, tagatose can potentially be used as a prescription drug additive to mask unpleasant tastes, and as a sweetener in toothpaste, mouthwash, and cosmetics such as flavoured lipstick |
| 2.7.4.3 | adenylate kinase |
more |
adenylate kinase is used as a soluble tag to facilitate MEK1R4F protein expression and its application in large-scale phosphorylated ERK1/2 preparation and purification |
| 2.7.6.2 | thiamine diphosphokinase |
more |
Administration of oxythiamine to animals produces primarily metabolic aberrations such as lethargy and anorexia while the administration of pyrithiamine to animals produces neurological problems similar to Wernicke-Korsakoff Syndrome. |
| 3.2.1.15 | endo-polygalacturonase |
more |
ADPG1 and ADPG2 are essential for silique dehiscence. ADPG2 and QRT2 contribute to floral organ abscission, while all three genes contribute to anther dehiscence |
| 3.2.1.17 | lysozyme |
more |
adsorption studies are conducted to investigate the effects of shaking rate, temperature, and initial lysozyme concentration on the uptake rate of lysozyme by the NaY zeolite (immobilization support) |
| 1.2.3.3 | pyruvate oxidase |
more |
aerobiosis makes the concerted action of lactate oxidase and pyruvate oxidase possible, enabling cells of Streptococcus pneumoniae to gain more ATP from glucose than under anaerobiosis |
| 1.3.8.7 | medium-chain acyl-CoA dehydrogenase |
more |
AFT10-1, which encodes an acyl-CoA dehydrogenase, is involved in the formation of the 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid moiety of the host-specific AF-toxin molecule |
| 3.4.24.16 | neurolysin |
more |
agaricoglycerides are devoid of activity in a large number of biochemical and cellular assays, emphasizing their selectivity towards neurolysin |
| 3.2.1.59 | glucan endo-1,3-alpha-glucosidase |
more |
Agn2p participates in the endolysis of the ascus wall by hydrolysing its (1,3)-alpha-glucan, thereby assisting in the release of ascospores |
| 1.11.2.1 | unspecific peroxygenase |
more |
Agrocybe aegerita peroxygenase is a particularly potent biocatalyst that fills the gap between cytochrome P450s and common heme peroxidases |
| 2.7.2.4 | aspartate kinase |
more |
AK DR1365 is not used for lysine biosynthesis but for threonine and methionine biosynteses, AK TTC0166 in Thermus thermophilus and AK DR1365 in Deinococcus radiodurans have different protein structure and evolutionary origins, but their functions are not different |
| 2.7.2.4 | aspartate kinase |
more |
AK has biological importance, as a target candidate for developing new antifungal and antibacterial compounds, because mammals cannot biosynthesize lysine. |
| 1.4.1.1 | alanine dehydrogenase |
more |
alanine dehydrogenase activity is necessary for an adequate cellular response to nitrogen starvation, is required for efficient degradation of phycobilisomes only during nitrogen starvation |
| 1.2.3.1 | aldehyde oxidase |
more |
aldehyde oxidase is involved in the chemo-reception of pheromonal stimuli in the antennae |
| 1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] |
more |
ALDH2 may have antioxidant properties. Yeast ALDH significantly and dose-dependently attenuates HX/XO-generated O2S- signal |
| 3.2.1.129 | endo-alpha-sialidase |
more |
almost complete removal of polysialic acid by endo-N injection into the brain 5 days after stimulation (return to normal polysialic acid levels after 11 weeks): no effect on proliferation, neurogenesis, and the fate of newborn cells in the hippocampus of rats without status epileptics. Increase of newborn cells in status epileptics rats compared to controls without significant difference between endo-N and vehicle treatment. However, endo-N treatment reduces the total number of newborn neurons (64%) upon induction of the status epileptics compared to vehicle treatment. No endo-N effect on hilar basal dendrite generation compared to vehicle control. No effect on doublecortin-expressing neuronal progenitor cells, and no effect on subpopulation of these cells with persistent basal dendrites compared to vehicle control. No difference in number, severity and duration of seizures between groups. Spatial learning deficit of status epilepticus mice is reduced by end-N treatment compared to vehicle control |
| 3.2.1.131 | xylan alpha-1,2-glucuronosidase |
more |
alpha-glucuronidase due to its catalytic properties may be of great importance in processes of enzymatic biomass conversion as well as a tool for altering rheological properties of glucuronoxylans |
| 1.2.1.105 | 2-oxoglutarate dehydrogenase system |
more |
alpha-ketoglutarate-involving reactions belong to the backbone of high-flux reactions, which is rather conserved in evolution |
| 1.8.3.1 | sulfite oxidase |
more |
alternative functional model ([Mo(TmMe)(O)2Cl]) of the metalloenzyme sulfite oxidase undergoes oxygen atom transfer chemistry and performs the primary function of the enzyme, sulfite oxidation |
| 1.2.1.19 | aminobutyraldehyde dehydrogenase |
more |
AMADH may participate in processes of adaptation to stress events caused by mechanical injury, which involve polyamine catabolism, GABA production and lignification |
| 3.4.19.1 | acylaminoacyl-peptidase |
more |
amino acid sequence of PMH displays high similarity to that of the Streptomyces acyl-peptide hydrolase. PMH is an aminopeptidase carrying a putative catalytic triad, Ser511-Asp593-His625, with broad substrate specificity |
| 2.7.4.33 | AMP-polyphosphate phosphotransferase |
more |
AMP is known to have potential for use as a reliable indicator in hygiene monitoring, the development of a sensitive method for detecting AMP, by using polyphosphate-AMP phosphotransferase and adenylate kinase in conjugation with firefly luciferase, is useful to detect food samples with high sensitivity |
| 2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
more |
AMPK is an earlier indicator of temperature stress in rock crabs than HSP70, especially during the initial response to high temperatures. AMPK activity is a cellular marker that indicates a thermal threshold, called the pejus temperature |
| 1.3.98.1 | dihydroorotate dehydrogenase (fumarate) |
more |
an ancient common ancestor of Euglenozoa had a mitochondrial DHOD whose descendant exists in Euglena gracilis |
| 1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
more |
an assay for sperm PHGPx activity emerges as a unique tool to evaluate semen quality for sire selection |
| 7.1.1.9 | cytochrome-c oxidase |
more |
an assembled complex IV helps to maintain complex I (NADH-ubiquinone oxidoreductase) in mammalian cells |
| 7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) |
more |
an assembled complex IV helps to maintain complex I in mammalian cells |
| 2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
more |
an elevation of enzyme Gnt-V activity leads to radiosensitivity and migration of small cell lung cancer cells by inducing epithelial-mesenchymal transition, EMT, thereby highlighting Gnt-V as a potential therapeutic target for the prevention of EMT-associated tumour radioresistance and migration |
| 1.7.2.8 | hydrazine dehydrogenase |
more |
anaerobic ammonium oxidation is a very good alternative for treatment of high strength nitrogenous waste streams. The introduction of anaerobic ammonium oxidation to N-removal would lead to a 90% reduction in operational costs. Anammox would replace the conventional denitrification step and would also save half of the nitrification aeration costs |
| 1.11.1.19 | dye decolorizing peroxidase |
more |
AnaPX is a useful alternative of horseradish peroxidase or fungal DyPs |
| 3.4.24.75 | lysostaphin |
more |
antistaphylococcal agent in clinical laboratories |
| 3.1.16.1 | spleen exonuclease |
more |
Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity |
| 3.4.22.60 | caspase-7 |
more |
apoptosis is preceded by proteolytic cleavage of e.g. caspase 7, prolonged nuclear localization of activated signal transducer and activator of transcription 1 results in apoptosis involving specific regulation of caspase pathway |
| 5.6.1.6 | channel-conductance-controlling ATPase |
more |
applicability of ten different antibodies under various fixation techniques for CFTR localization in fresh-brushed nasal epithelia cells collected from cystic fibrosis patients homozygous for F508del and control individuals |
| 1.1.1.118 | glucose 1-dehydrogenase (NAD+) |
more |
application in NADPH regeneration for the asymmetric reduction of haloketone by a carbonyl reductase in organic solvent/buffer system |
| 3.2.1.73 | licheninase |
more |
application of lichenases is attractive and promising for biocatalytic conversion of biomass, in particular, in the areas of their biotechnological application, such as brewing industry, animal feed manufacture, and biofuel production |
| 3.2.1.73 | licheninase |
more |
application of lichenases is attractive and promising for biocatalytic conversion of biomass, in particular, in the areas of their biotechnological application, such as brewing industry, animal feed manufacture, and biofuel/bioethanol production |
| 1.1.5.5 | alcohol dehydrogenase (quinone) |
more |
applications of PQQ-ADH in bioelectrocatalyst for biosensors and biofuel cells, amperometric determination of ethanol is a potential application for the PQQ-ADH electrode, overview |
| 1.1.5.5 | alcohol dehydrogenase (quinone) |
more |
applications of PQQ-ADH in bioelectrocatalyst for biosensors and biofuel cells, amperometric determination of ethanol is a potential application for the PQQ-ADH electrode, overview. Development of a DET-based biofuel system by combination of electrodes coated with FAD-dependent fructose dehydrogenase of Gluconobacter sp. as an anode and laccase of mushroom as a cathode |
| 7.1.1.9 | cytochrome-c oxidase |
more |
Arabidopsis thaliana COX19 genes encode functional homologues of the yeast metal chaperone. Smaller COX19-1 isoform, but not the larger one, is able to restore growth on non-fermentable carbon sources when expressed in a yeast cox19 null mutant. Induction by biotic and abiotic stress factors may indicate a relevant role of this protein in the biogenesis of cytochrome c oxidase to replace damaged forms of the enzyme. COX19 has additional functions besides its participation in COX assembly as, for example, metal transport, detoxification, or general protection against oxidative stress |
| 2.7.2.3 | phosphoglycerate kinase |
more |
Arg148 as a key residue involved in open-to-closed transition, during catalysis, a conformational change occurs that brings the N- and C-domains of PGK closer together |
| 2.7.10.1 | receptor protein-tyrosine kinase |
more |
around 38% tyrosine phosphorylation events from Drosophila RTK proteins conserved on 185 human proteins are confirmed in vivo tyrosine phosphorylation events |
| 1.14.13.84 | 4-hydroxyacetophenone monooxygenase |
more |
as acylcatechols are valuable synthons for the fine chemical industry, HAPMO might develop as a useful biocatalytic tool |
| 3.4.22.7 | asclepain |
more |
asclepain f is revealed as a successful enzyme for biocatalysis of protein hydrolysis processes at alkaline pH. It has a broad substrate specificity and is capable of selectively degrading the fractions of soy proteins and improving its functional properties |
| 1.3.2.3 | L-galactonolactone dehydrogenase |
more |
ascorbate, which fulfils well recognized, signalling functions in plants, decliney in a regulated manner during nodule development, indicates a development-related shift in redox-linked metabolite cross-talk that underpins the development and aging processes |
| 2.7.2.4 | aspartate kinase |
more |
ASK1 and ASK2 share a high degree of identity with each other, there is one amino acid difference in the Ask2 enzymes of Oh545o2 and Oh51Ao2 |
| 2.7.11.25 | mitogen-activated protein kinase kinase kinase |
more |
ASK2, a highly related serine/threonine kinase to ASK1, functions as a MAP3K only in a heteromeric complex with ASK1 |
| 3.4.24.33 | peptidyl-Asp metalloendopeptidase |
more |
AspN is shown to be an alternative protease for in-capillary digestion (during capillary electrophoresis), AspN behaves very similarly to trypsin |
| 1.14.15.4 | steroid 11beta-monooxygenase |
more |
assays can be used for assessing the potency and selectivity of CYP11B2 inhibitors for the treatment of hypertension and heart failure |
| 3.4.24.80 | membrane-type matrix metalloproteinase-1 |
more |
association of MT1-MMP with different membrane subdomains may be crucial in the control of its different activities like cell migration, invasion or MT1-MMP-dependent signaling pathways |
| 2.1.1.148 | thymidylate synthase (FAD) |
more |
autoregulates its own translation, RNA stem-loop structure acts as an inhibitory regulator of translation by preventing the binding of its Shine-Dalgarno-like sequence by positioning it in the stem region, addition of Thy1 into the in vitro translation system also inhibits translation |
| 2.7.10.1 | receptor protein-tyrosine kinase |
more |
B-cell proliferation and the induction of increased surface expression of costimulatory ligand CD86 by PorB are dependent on PTK activity and not Erk1/2 activation |
| 1.20.9.1 | arsenate reductase (azurin) |
more |
bacterial arsenite oxidase genes are not only phylogenetically diverse, but also ecologically widespread. Genes for aerobic arsenite oxidation are widely distributed in the bacterial domain, are widespread in soil-water systems containing arsenite, and play a critical role in the biogeochemical cycling of arsenite |
