EC Number   |
Natural Substrates |
|---|
   3.4.24.B11 | aggrecan + H2O |
- |
| 3.4.24.B11 | aggrecan + H2O |
substrate is a cartilage proteoglycan |
| 3.4.24.B11 | Collagen type I + H2O |
- |
| 3.4.24.B11 | more |
enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation |
| 3.4.24.B11 | more |
enzyme inhibits endothelial cell proliferation, but not fibroblast or smooth muscle growth |
| 3.4.24.B11 | more |
enzyme is genetically regulated by progesteron in the ovulation process |
| 3.4.24.B11 | more |
enzyme plays a role in cell-cell and cell-matrix interactions, in cell adhesion and growth factor signaling |
| 3.4.24.B11 | more |
interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium |
| 3.4.24.B11 | more |
vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor, interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium |
| 3.4.24.B11 | proteins + H2O |
- |
