EC Number   |
Natural Substrates |
|---|
   3.1.3.16 | fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase + H2O |
heterotrimeric phosphatase 2A catalyzing the dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase |
| 3.1.3.16 | more |
ceramide-induced cell survival mechanism, overview |
| 3.1.3.16 | more |
in vivo expression and response pattern of PP2A gene to environmental stress |
| 3.1.3.16 | more |
PP1 contains a surface hydrophobic pocket on the catalytic subunit which is important in recognizing cellular regulators via their consensus RVxF motifs, regulation of the enzyme, overview |
| 3.1.3.16 | more |
PP2A is a multifunctional enzyme, direct interaction with the adenovirus E4orf4 protein via the regulatory subunit initiation virus-induced growth arrest in yeast cells, signal transduction is mediated by Cdc55 interacting with both PP2A catalytic subunit in absence of the Tpd3 subunit and E4orf4, mechanism involving the Tpd3 yeast subunit, overview |
| 3.1.3.16 | more |
PP2A is involved in central sensitization, PP2A negatively regulates the phosphorylation of N-methyl-D-aspartate, NMDA, receptors in response to capsaicin induction in the spinal cord |
| 3.1.3.16 | more |
PP2A is involved in the maintenance of E-cadherin-mediated cell-cell adhesion through recruitment of IQGAP1, an effector of small GTPase Rac |
| 3.1.3.16 | more |
PP2A modulates Akt activity, role of PP2A holoenzyme and subunits in MAPK signaling pathways, overview |
| 3.1.3.16 | more |
PP2A regulates a wide variety of cellular signal transduction pathways, and performs positive regulation of Raf1-MEK1/2-ERK1/2 signaling at multiple steps of the pathway, overview |
| 3.1.3.16 | more |
PP4 activates c-Jun N-terminal kinase JNK-1 and is required for JNK-1 stability in prostate cancer cells, PP4 is involved in the MAPK signaling pathway, overview |
