EC Number |
Natural Substrates |
---|
3.1.1.25 | homocysteine thiolactone + H2O |
- |
3.1.1.25 | more |
PON's native enzyme activity is as a lactonase, the lactonase function of PON1 can protect transgenic flies from lethal Pseudomonas aeruginosa infection |
3.1.1.25 | more |
PON1 is a lipolactonase that associates with HDL-apolipoprotein A-I and thereby plays a role in the prevention of atherosclerosis |
3.1.1.25 | more |
PON3 is not able to prevent macrophage oxidative stress, however, is able to retard macrophage-induced low-density lipoprotein oxidation |
3.1.1.25 | more |
the active site of the enzyme is characterized by two distinct binding regions, the hydrophobic binding site for arylesters/lactones and the paraoxon binding site for phosphotriesters |
3.1.1.25 | N-(3-oxodecanoyl)-L-homoserine lactone + H2O |
the best, possibly natural, substrate of wild-type enzyme |