EC Number |
Natural Substrates |
---|
1.8.1.B1 | 2 GSH + NADP+ |
- |
1.8.1.B1 | glutathione disulfide + NADPH + H+ |
- |
1.8.1.B1 | glutathione disulfide + NADPH + H+ |
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host |
1.8.1.B1 | glutathione disulfide + NADPH + H+ |
the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites |
1.8.1.B1 | GSSG + NADPH + H+ |
- |
1.8.1.B1 | more |
the parasite-specific enzyme thioredoxin glutathione reductase is a component of the defense system |
1.8.1.B1 | thioredoxin + NADP+ |
- |
1.8.1.B1 | thioredoxin disulfide + NADPH + H+ |
- |
1.8.1.B1 | thioredoxin disulfide + NADPH + H+ |
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host |