EC Number |
Inhibitors |
Structure |
---|
2.7.4.21 | 1,3,4,5,6-inositol pentakisphosphate |
IC50 for inositol hexakisphosphate kinase activity is 0.022 mM, IC50 for ATP synthase activity is 0.0128 mM |
|
2.7.4.21 | 2,5-O-benzyl-myo-inositol 1,3,4,6-tetrakisphosphate |
activates the ATP hydrolysis activity and inhibits the PPIP5K2 activity and InsP6 kinase activity, and the 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme. The compound can inhibit inositol phosphate kinase activity without occupying the catalytic site |
|
2.7.4.21 | 2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate |
stimulates ATP hydrolysis 9fold, but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme. The compound can inhibit inositol phosphate kinase activity without occupying the catalytic site |
|
2.7.4.21 | 2-O-benzyl-5-O-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate |
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme |
|
2.7.4.21 | 2-O-benzyl-myo-inositol 1,2,3,4,6-pentakisphosphate |
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme |
|
2.7.4.21 | 5-O-alpha-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate |
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme |
|
2.7.4.21 | 5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate |
stimulates ATP hydrolysis 5fold, but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme |
|
2.7.4.21 | 6-hydroxy-DL-DOPA |
- |
|
2.7.4.21 | C8-PtdIns(4,5)P2 |
0.05 mM, inhibits 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate dephosphorylation by approximately 60% |
|
2.7.4.21 | diphosphoinositol pentakisphosphate |
IC50 for inositol hexakisphosphate kinase activity is 0.0066 mM, IC50 for ATP synthase activity is 0.0018 mM |
|