EC Number   |
Inhibitors |
Structure |
|---|
   2.7.1.151 | abscisic acid |
In ten-day-old seedlings grown on MS medium, AtIpk2b transcript level decreased. |
   |
| 2.7.1.151 | aurintricarboxylic acid |
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, strong inhibition, IC50 is 44 nM |
|
| 2.7.1.151 | chlorogenic acid |
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 0.0012 mM |
|
| 2.7.1.151 | ellagic acid |
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 0.0014 mM |
|
| 2.7.1.151 | gossypol |
mixed-type versus ATP, noncompetitive versus 1D-myo-inositol 1,4,5-trisphosphate, slight inhibition, IC50 is 0.0034 mM |
|
| 2.7.1.151 | inositol(1,3,4)-trisphosphate |
potently inhibits hITPK1 activity towards insositol (3,4,5,6)-tetrakisphosphate, IC50: 0.0076 mM |
|
| 2.7.1.151 | inositol(3,5,6)-trisphosphate |
IC50: 0.1 mM |
|
| 2.7.1.151 | more |
inhibitory effects are not due to inactivating aggregation of the enzyme, no inhibition by quercetin, 3',4',7,8-tetrahydroxyflavone, myricetin, hypericin, epigallocatechin-3-gallate, and epicatechin-3-gallate, the enzyme contains a unique basic segment of 105 amino acids, which is inserted between the SSLL motif and the DFG motif, being probably involved in inhibition by acidic polyphenols |
|
| 2.7.1.151 | more |
no inhibition by wortmannin and LY294002 |
|
| 2.7.1.151 | more |
an enzyme-deficient mutant strain is resistant to inhibition by wortmannin, while transformation with the wild-type enzyme reverses the effect |
|
