EC Number   |
Inhibitors |
Structure |
|---|
    1.14.14.1 | 1-aminobenzotriazole |
moderately prohibits spontaneous mutations of V79-hCYP2E1-hSULT1A1 cells. In combination with SULT1A1 inhibitor pentachlorophenol completely prohibits spontaneous mutations of V79-hCYP2E1-hSULT1A1 cells |
   |
| 1.14.14.1 | 17alpha-ethynylestradiol |
reactive intermediates of 17alpha-ethynylestradiol inactivate P450s in a NADPH-dependent mechanism-based manner by a combination of heme alkylation and apoprotein modification |
|
| 1.14.14.1 | 8-methoxypsoralen |
- |
|
| 1.14.14.1 | anastrozole |
profiling inhibition of probe 1 labeling of P450 19A1, inhibits labeling of P450 2C9 by probe 5 |
|
| 1.14.14.1 | Atrazine |
a herbicide |
|
| 1.14.14.1 | bifonazole |
an anti-fungal drug, complex formation with CYP2B4, inhibits monooxygenase activity and induces a type II binding spectrum in CYP2B4 mutant H226Y, plastic regions efficiently, because conformational changes are clustered, the 2B4-bifonazole dimer is different from the ligand-free 2B4dH dimer, which involves the coordination of His226 to the heme iron of the other monomer |
|
| 1.14.14.1 | bifonazole |
CYP19 |
|
| 1.14.14.1 | bitertanol |
7-ethoxyresorufin O-deethylation is inhibited by the fungicide bitertanol, IC50: 800-900 nM |
|
| 1.14.14.1 | Cd2+ |
strong inhibition of 7-ethoxyresorufin-O-deethylase, EROD, and a lower inhibition of 7-ethoxycoumarin-O-deethylase, ECOD, activity, cadmium causes damage to the protein structure |
|
| 1.14.14.1 | chlorotoluron |
metabolism in sensitive plants is induced by blue light |
|
