EC Number   |
Activating Compound |
Reference |
|---|
   6.5.1.1 | apurine/apyrimidinic endonuclease I |
stimulation of DNA ligase activity, inhibition if the DNA ligase I substrate has a tetrahydrofuran residue on the 5'-downstream primer of a nick, simulating a reduced abasic site |
652322 |
| 6.5.1.1 | bovine serum albumin |
stimulates |
1906 |
| 6.5.1.1 | dithiothreitol |
required for optimal activity |
1922 |
| 6.5.1.1 | dithiothreitol |
required for optimal activity of DNA ligase I, but not for DNA ligase II activity |
1965 |
| 6.5.1.1 | DRB0098 protein |
DNA ligase activity of LigB is severalfold stimulated by PprA in the presence of the recombinant DRB0098 protein |
714069 |
| 6.5.1.1 | Hexamine cobalt chloride |
maximal stimulation at 0.001-0.0015 mM, blunt end ligation is stimulated 50fold, but cohesive end ligation only 5fold |
1910 |
| 6.5.1.1 | more |
human fibroblast line GM1492, but not several related fibroblast lines, expresses substantial amounts of a heat-stable protease-sensitive factor, which stimulates calf thymus DNA ligase I |
1906 |
| 6.5.1.1 | more |
LigI activity is strongly linked to proliferating cell nuclear antigen, the interaction between both factors is essential for the recruitment of LigI to replication foci and sites of DNA damage, replication efficiency is reduced on CTG/CAG templates with a defective LigI |
709055 |
| 6.5.1.1 | more |
the enzyme interacts with the proliferating cell nuclear antigen heterotrimer |
725969 |
| 6.5.1.1 | phosphate |
DNA ligase I is a phosphoprotein, dephosphorylation causes drastic reduction in enzyme activity |
1906 |
