1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Acremonium chrysogenum	-	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Amycolatopsis lactamdurans	-	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Aspergillus nidulans	P05326, P05326, P05326	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Flavobacterium sp.	-	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Penicillium chrysogenum	-	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Streptomyces clavuligerus	-	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Streptomyces jumonjinensis	-	
1.21.3.1	isopenicillin-N synthase	oxidative cyclization	-	Streptomyces microflavus	-	
1.21.3.3	reticuline oxidase	oxidative cyclization	-	Eschscholzia californica	P30986, P30986