1.2.1.11 aspartate-semialdehyde dehydrogenase spermidine biosynthesis II 1.5.1.43 carboxynorspermidine synthase spermidine biosynthesis II 2.7.2.4 aspartate kinase spermidine biosynthesis II 4.1.1.96 carboxynorspermidine decarboxylase spermidine biosynthesis II