2.1.1.46 isoflavone 4'-O-methyltransferase formononetin biosynthesis 2.1.1.212 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase formononetin biosynthesis 4.2.1.105 2-hydroxyisoflavanone dehydratase formononetin biosynthesis