1.1.1.362 aklaviketone reductase daunorubicin biosynthesis 1.14.13.180 aklavinone 12-hydroxylase daunorubicin biosynthesis 1.14.13.181 13-deoxydaunorubicin hydroxylase daunorubicin biosynthesis 2.1.1.288 aklanonic acid methyltransferase daunorubicin biosynthesis 2.1.1.292 carminomycin 4-O-methyltransferase daunorubicin biosynthesis 5.5.1.23 aklanonic acid methyl ester cyclase daunorubicin biosynthesis