2.3.1.245 3-hydroxy-5-phosphooxypentane-2,4-dione thiolase autoinducer AI-2 degradation 2.7.1.189 autoinducer-2 kinase autoinducer AI-2 degradation 5.3.1.32 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase autoinducer AI-2 degradation