Information on EC 5.4.99.12 - tRNA pseudouridine38-40 synthase:

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Specific data for protein or organism
This record set is specific for:UniProt-Accession: P31115
Specific annotated data for the given UniProt-Accession is marked in orange!


nonspecific: SELECT distinct Reaction,Reaction_id,Commentary,Organism,Literature FROM Reaction_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) OR ( Literature='' AND Organism='' AND Commentary='') ) AND (protein_ID != 274345 OR protein_ID IS NULL)

nonspecific: SELECT distinct Reaction_Type,Organism,Commentary,Literature FROM Reaction_Type_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) OR ( Literature='' AND Organism='' AND Commentary='') ) AND (protein_ID != 274345 OR protein_ID IS NULL)

nonspecific: SELECT distinct Synonyms,Organism,Commentary,Literature FROM Synonyms_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) OR ( Literature='' AND Organism='' AND Commentary='') ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Synonyms

nonspecific: SELECT distinct Substrates,Products,id,Organism_Substrates,Commentary_Substrates, Literature_Substrates, Commentary_Products, Literature_Products,Reversibility FROM Substrates_Products_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism_Substrates='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Substrates

nonspecific: SELECT distinct Substrates,Products,id,Organism_Substrates,Commentary_Substrates,Literature_Substrates,Commentary_Products,Literature_Products,Reversibility FROM Natural_Substrates_Products_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism_Substrates='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL)

nonspecific: SELECT distinct Cofactor,Organism,Commentary,Literature,Filename FROM Cofactor_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Cofactor

nonspecific: SELECT distinct Metals_Ions,Organism,Commentary, Literature FROM Metals_Ions_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Metals_Ions

nonspecific: SELECT distinct Inhibitors, Organism, Commentary, Literature,Filename FROM Inhibitors_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Inhibitors

nonspecific: SELECT distinct Activating_Compound, Organism, Commentary, Literature,Filename FROM Activating_Compound_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Activating_Compound

nonspecific: SELECT distinct KM_Value,KM_Value_Maximum, Substrate,Organism, Commentary, Literature, Filename FROM KM_Value_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Substrate

nonspecific: SELECT distinct Turnover_Number, Turnover_Number_Maximum, Substrate,Organism,Commentary, Literature, Filename FROM Turnover_Number_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Substrate

nonspecific: SELECT distinct KI_Value,KI_Value_Maximum, Inhibitor,Organism, Commentary, Literature, Filename FROM KI_Value_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Inhibitor

nonspecific: SELECT distinct IC50_Value,IC50_Value_Maximum, Inhibitor,Organism, Commentary, Literature, Filename FROM IC50_Value_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Inhibitor

nonspecific: SELECT distinct Specific_Activity, Specific_Activity_Maximum, Organism ,Commentary, Literature FROM Specific_Activity_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Specific_Activity

nonspecific: SELECT distinct pH_Optimum, pH_Optimum_Maximum, Organism, Commentary, Literature FROM pH_Optimum_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY pH_Optimum ASC

nonspecific: SELECT distinct pH_Range,pH_Range_Maximum, Organism,Commentary, Literature FROM pH_Range_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY pH_Range ASC

nonspecific: SELECT distinct Temperature_Optimum, Temperature_Optimum_Maximum, Organism, Commentary, Literature FROM Temperature_Optimum_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Temperature_Optimum ASC

nonspecific: SELECT distinct Temperature_Range, Temperature_Range_Maximum, Organism, Commentary, Literature FROM Temperature_Range_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Temperature_Range ASC

nonspecific: SELECT distinct pI_Value,pI_Value_Maximum, Organism,Commentary, Literature FROM pI_Value_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY pI_Value ASC

nonspecific: SELECT distinct Source_Tissue, Organism, Commentary, Literature, Textmining FROM Source_Tissue_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND Textmining=0 AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Source_Tissue

nonspecific: SELECT distinct Localization, Organism, Commentary, id_go, Literature, Textmining FROM Localization_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND Textmining=0 AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Localization

nonspecific: SELECT distinct Molecular_Weight, Molecular_Weight_Maximum, Organism, Commentary, Literature FROM Molecular_Weight_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Molecular_Weight

nonspecific: SELECT distinct Subunits, Organism, Commentary, Literature FROM Subunits_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Subunits

nonspecific: SELECT distinct Posttranslational_Modification, Organism, Commentary, Literature FROM Posttranslational_Modification_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Commentary, Organism, Literature FROM Crystallization_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct pH_Stability,pH_Stability_Maximum, Organism, Commentary, Literature FROM pH_Stability_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY pH_Stability ASC

nonspecific: SELECT distinct Temperature_Stability,Temperature_Stability_Maximum, Organism, Commentary, Literature FROM Temperature_Stability_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Temperature_Stability

nonspecific: SELECT distinct General_Stability, Organism, Literature FROM General_Stability_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Organic_Solvent, Organism, Commentary, Literature FROM Organic_Solvent_Stability_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organic_Solvent

nonspecific: SELECT distinct Oxidation_Stability,Organism,Literature FROM Oxidation_Stability_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Storage_Stability, Organism, Literature FROM Storage_Stability_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Commentary, Organism, Literature FROM Purification_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Commentary, Organism, Literature FROM Cloned_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Engineering, Organism, Commentary, Literature FROM Engineering_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Commentary, Organism, Literature FROM Renatured_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism

nonspecific: SELECT distinct Application,Organism,Commentary,Literature FROM Application_ps WHERE EC_Number = '5.4.99.12' AND ( (Organism='Agaricus bisporus' ) ) AND (protein_ID != 274345 OR protein_ID IS NULL) ORDER BY Organism
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria


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EC NUMBERCOMMENTARY
5.4.99.12-

RECOMMENDED NAMEGeneOntology No.
tRNA pseudouridine38-40 synthaseGO:0009982

REACTIONREACTION DIAGRAMCOMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

REACTION TYPEORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

PATHWAYKEGG LinkMetaCyc Link
No entries in this field

SYSTEMATIC NAMEIUBMB Comments
tRNA-uridine38-40 uracil mutaseThe uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures [1].

SYNONYMSORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

CAS REGISTRY NUMBERCOMMENTARY
430429-15-5-
61506-89-6-

ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DB SOURCE
No entries in this field

GENERAL INFORMATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SUBSTRATEPRODUCT                      REACTION DIAGRAMORGANISM UNIPROT ACCESSION NO. COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
No entries in this field

NATURAL SUBSTRATESNATURAL PRODUCTSREACTION DIAGRAMORGANISM UNIPROT ACCESSION NO.COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
No entries in this field

COFACTORORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATUREIMAGE
No entries in this field

METALS and IONS ORGANISM UNIPROT ACCESSION NO.COMMENTARY LITERATURE
No entries in this field

INHIBITORSORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

ACTIVATING COMPOUNDORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

KM VALUE [mM]KM VALUE [mM] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

TURNOVER NUMBER [1/s] TURNOVER NUMBER MAXIMUM[1/s] SUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

kcat/KM VALUE [1/mMs-1]kcat/KM VALUE [1/mMs-1] MaximumSUBSTRATEORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

Ki VALUE [mM]Ki VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

IC50 VALUE [mM]IC50 VALUE [mM] MaximumINHIBITORORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE IMAGE
No entries in this field

SPECIFIC ACTIVITY [µmol/min/mg] SPECIFIC ACTIVITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pH OPTIMUMpH MAXIMUMORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

pH RANGEpH RANGE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE OPTIMUMTEMPERATURE OPTIMUM MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

TEMPERATURE RANGE TEMPERATURE MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

pI VALUEpI VALUE MAXIMUMORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

SOURCE TISSUE ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE SOURCE
No entries in this field

LOCALIZATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY GeneOntology No. LITERATURE SOURCE
No entries in this field

PDBSCOPCATHORGANISM
No entries in this field

MOLECULAR WEIGHT MOLECULAR WEIGHT MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

SUBUNITS ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

POSTTRANSLATIONAL MODIFICATION ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

Crystallization/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

pH STABILITYpH STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

TEMPERATURE STABILITYTEMPERATURE STABILITY MAXIMUM ORGANISM UNIPROT ACCESSION NO. COMMENTARYLITERATURE
No entries in this field

GENERAL STABILITYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

ORGANIC SOLVENT ORGANISM UNIPROT ACCESSION NO. COMMENTARY LITERATURE
No entries in this field

OXIDATION STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

STORAGE STABILITY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Purification/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

Cloned/COMMENTARY ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

EXPRESSION ORGANISM UNIPROT ACCESSION NO. LITERATURE
No entries in this field

ENGINEERINGORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

Renatured/COMMENTARYORGANISM UNIPROT ACCESSION NO.LITERATURE
No entries in this field

APPLICATIONORGANISM UNIPROT ACCESSION NO.COMMENTARYLITERATURE
No entries in this field

REF. AUTHORS TITLE JOURNAL VOL. PAGES YEAR ORGANISM (UNIPROT ACCESSION NO.)LINK TO PUBMEDSOURCE

LINKS TO OTHER DATABASES (specific for EC-Number 5.4.99.12)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)